Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRP | O00591 | 9/20 | 0.52 |
| ▸ | GABRD | O14764 | 9/20 | 0.52 |
| ▸ | GABRA1 | P14867 | 9/20 | 0.52 |
| ▸ | GABRB1 | P18505 | 9/20 | 0.52 |
| ▸ | GABRG2 | P18507 | 9/20 | 0.52 |
| ▸ | GABRB3 | P28472 | 9/20 | 0.52 |
| ▸ | GABRA5 | P31644 | 9/20 | 0.52 |
| ▸ | GABRA3 | P34903 | 9/20 | 0.52 |
| ▸ | GABRA2 | P47869 | 9/20 | 0.52 |
| ▸ | GABRB2 | P47870 | 9/20 | 0.52 |
| ▸ | GABRA4 | P48169 | 9/20 | 0.52 |
| ▸ | GABRE | P78334 | 9/20 | 0.52 |
| ▸ | GABRA6 | Q16445 | 9/20 | 0.52 |
| ▸ | GABRG1 | Q8N1C3 | 9/20 | 0.52 |
| ▸ | GABRG3 | Q99928 | 9/20 | 0.52 |
| ▸ | GABRQ | Q9UN88 | 9/20 | 0.52 |
| ▸ | TNKS | O95271 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15545789 | 0.91 | GABRP (0.51) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL13717975 | 0.83 | AR (0.41) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL8670 | 0.81 | GABRP (0.57) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL16459025 | 0.79 | GABRP (0.52) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL15528283 | 0.79 | GABRP (0.52) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL15599897 | 0.79 | GABRP (0.52) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| Dimethyl Sulfoxide SCHEMBL21055832 | 0.78 | AR (0.37) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL16279463 | 0.78 | GABRP (0.48) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL8856 | 0.77 | GABRA1 (0.53) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL28019891 | 0.77 | GABRP (0.53) | GABRPGABRDGABRA1GABRB1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 62 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210403475-A1 | NOVEL SELECTIVE PI3K DELTA INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2021-12-30 | — | — | US | disclosed |
| US-20210403475-A1 | NOVEL SELECTIVE PI3K DELTA INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2021-12-30 | — | — | US | disclosed |
| US-10981919-B2 | Selective PI3K delta inhibitors | RHIZEN PHARMACEUTICALS SA (CH) | 2021-04-20 | — | — | US | disclosed |
| US-10981919-B2 | Selective PI3K delta inhibitors | RHIZEN PHARMACEUTICALS SA (CH) | 2021-04-20 | — | — | US | disclosed |
| EP-3756686-A1 | COMBINATION OF ANTI-CD20 ANTIBODY AND PI3 KINASE SELECTIVE INHIBITOR | TG Therapeutics Inc. (US) | 2020-12-30 | — | — | EP | disclosed |
| EP-3756686-A1 | COMBINATION OF ANTI-CD20 ANTIBODY AND PI3 KINASE SELECTIVE INHIBITOR | TG Therapeutics Inc. (US) | 2020-12-30 | — | — | EP | disclosed |
| US-20200323981-A1 | Combination of Anti-CD20 Antibody and PI3 Kinase Selective Inhibitor | BLUE OWL CAPITAL CORPORATION | 2020-10-15 | — | — | US | disclosed |
| US-20200323981-A1 | Combination of Anti-CD20 Antibody and PI3 Kinase Selective Inhibitor | BLUE OWL CAPITAL CORPORATION | 2020-10-15 | — | — | US | disclosed |
| US-20200270258-A1 | NOVEL SELECTIVE PI3K DELTA INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2020-08-27 | — | — | US | disclosed |
| US-20200270258-A1 | NOVEL SELECTIVE PI3K DELTA INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2020-08-27 | — | — | US | disclosed |
| US-9150579-B2 | Selective PI3K delta inhibitors | RHIZEN PHARMACEUTICALS SA (CH) | 2015-10-06 | — | — | US | disclosed |
| EP-2914343-A1 | COMBINATION OF ANTI-CD20 ANTIBODY AND PI3 KINASE SELECTIVE INHIBITOR | TG Therapeutics Inc. (US) | 2015-09-09 | — | — | EP | disclosed |
| EP-2870157-A1 | SELECTIVE PI3K DELTA INHIBITORS | Rhizen Pharmaceuticals S.A. (CH) | 2015-05-13 | — | — | EP | disclosed |
| WO-2014071125-A1 | COMBINATION OF ANTI-CD20 ANTIBODY AND PI3 KINASE SELECTIVE INHIBITOR | TG THERAPEUTICS, INC. (US) | 2014-05-08 | — | — | WO | disclosed |
| WO-2014071125-A1 | COMBINATION OF ANTI-CD20 ANTIBODY AND PI3 KINASE SELECTIVE INHIBITOR | TG THERAPEUTICS, INC. (US) | 2014-05-08 | — | — | WO | disclosed |
| US-20140011819-A1 | NOVEL SELECTIVE PI3K DELTA INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2014-01-09 | — | — | US | disclosed |
| US-20140011819-A1 | NOVEL SELECTIVE PI3K DELTA INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2014-01-09 | — | — | US | disclosed |
| US-20140011819-A1 | NOVEL SELECTIVE PI3K DELTA INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2014-01-09 | — | — | US | disclosed |
| WO-2014006572-A1 | SELECTIVE PI3K DELTA INHIBITORS | RHIZEN PHARMACEUTICALS SA (CH) | 2014-01-09 | — | — | WO | disclosed |
| WO-2014006572-A1 | SELECTIVE PI3K DELTA INHIBITORS | RHIZEN PHARMACEUTICALS SA (CH) | 2014-01-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200323981-A1 | Combination of Anti-CD20 Antibody and PI3 Kinase Selective Inhibitor | PIK3R4, PIK3R5, PIK3R1 | GABRP 1294/4885GABRD 3606/4885GABRA1 733/4885 |
| US-20140011819-A1 | NOVEL SELECTIVE PI3K DELTA INHIBITORS | PIK3CD, PIK3R5, PIK3C2B | GABRP 502/4885GABRD 1117/4885GABRA1 1938/4885 |
| US-20200270258-A1 | NOVEL SELECTIVE PI3K DELTA INHIBITORS | PIK3CD, PIK3R5, PIK3C2B | GABRP 502/4885GABRD 1117/4885GABRA1 1938/4885 |
| US-10981919-B2 | Selective PI3K delta inhibitors | PIK3CD, PIK3C2B, PIK3R5 | GABRP 435/4885GABRD 931/4885GABRA1 1821/4885 |
| US-20210403475-A1 | NOVEL SELECTIVE PI3K DELTA INHIBITORS | PIK3CD, PIK3R5, PIK3C2B | GABRP 502/4885GABRD 1117/4885GABRA1 1938/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.