Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 9/20 | 0.62 |
| ▸ | PPARG | P37231 | 7/20 | 0.62 |
| ▸ | PPARD | Q03181 | 3/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.62 |
| ▸ | GMNN | O75496 | 1/20 | 0.62 |
| ▸ | USP2 | O75604 | 1/20 | 0.62 |
| ▸ | USP1 | O94782 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.62 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18976829 | 0.77 | NPC1 (0.51) | ALDH1A1LMNANPC1L3MBTL1 | |
| Gw7647 SCHEMBL361372 | 0.77 | PPARA (1.00) | PPARAPPARGPPARDNPSR1GMNN | |
| SCHEMBL22100299 | 0.76 | PPARA (0.98) | PPARAPPARGPPARDNPSR1GMNN | |
| SCHEMBL6552622 | 0.74 | PPARA (0.80) | PPARAPPARGPPARDNPSR1GMNN | |
| Ammonia Solution, Strong SCHEMBL6304391 | 0.72 | HRH3 (0.48) | LMNANPC1 | |
| SCHEMBL16191317 | 0.72 | NPC1 (0.54) | ALDH1A1LMNANPC1L3MBTL1 | |
| SCHEMBL10888932 | 0.70 | PPARA (0.47) | PPARAPPARGPPARDCYP3A4MAPT | |
| SCHEMBL5051860 | 0.70 | EPHX2 (0.68) | ALDH1A1LMNAPOLBNPC1RAB9A | |
| SCHEMBL11950268 | 0.69 | NPC1 (0.55) | ALDH1A1LMNATP53POLBNPC1 | |
| SCHEMBL17471269 | 0.68 | PPARA (0.70) | PPARAPPARGPPARDNPSR1GMNN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014015318-A1 | SOLUBLE COMPOUNDS FOR IMPROVED GENE THERAPY METHODS | BLUEBIRD BIO, INC. (US) | 2014-01-23 | — | — | WO | disclosed |