Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN2 | Q96KS0 | 6/20 | 0.46 |
| ▸ | EGLN1 | Q9GZT9 | 6/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.40 |
| ▸ | THRA | P10827 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.39 |
| ▸ | GABRP | O00591 | 1/20 | 0.39 |
| ▸ | GABRD | O14764 | 1/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.39 |
| ▸ | GABRE | P78334 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15549349 | 0.92 | EGLN2 (0.53) | EGLN2EGLN1THRATHRB | |
| SCHEMBL15548046 | 0.91 | EGLN2 (0.53) | EGLN2EGLN1THRATHRB | |
| SCHEMBL6060882 | 0.87 | MTNR1A (0.43) | EGLN2EGLN1MTNR1AMTNR1BGABRA1 | |
| SCHEMBL15547324 | 0.85 | EGLN1 (0.59) | EGLN2EGLN1THRATHRB | |
| SCHEMBL16844175 | 0.84 | EGLN2 (0.55) | EGLN2EGLN1THRATHRB | |
| SCHEMBL15268696 | 0.82 | EGLN1 (0.55) | EGLN2EGLN1THRATHRB | |
| SCHEMBL6060086 | 0.78 | EGLN2 (0.48) | EGLN2EGLN1GABRA1GABRG2GABRB3 | |
| SCHEMBL6060451 | 0.77 | GABRA1 (0.41) | EGLN2MTNR1AMTNR1BGABRA1GABRG2 | |
| SCHEMBL2015417 | 0.77 | HIF1A (0.43) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL15268444 | 0.77 | EGLN2 (0.65) | EGLN2EGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2872487-A1 | PROCESS FOR MAKING ISOQUINOLINE COMPOUNDS | Fibrogen, Inc. (US) | 2015-05-20 | — | — | EP | disclosed |
| WO-2014014834-A1 | PROCESS FOR MAKING ISOQUINOLINE COMPOUNDS | FIBROGEN, INC. (US) | 2014-01-23 | — | — | WO | disclosed |