Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 18/20 | 1.00 |
| ▸ | TNKS2 | Q9H2K2 | 18/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12549629 | 0.84 | TNKS (1.00) | TNKSTNKS2KDM4EMEN1LMNA | |
| SCHEMBL15547644 | 0.71 | TNKS (0.82) | TNKSTNKS2 | |
| SCHEMBL15547646 | 0.71 | TNKS (0.82) | TNKSTNKS2 | |
| SCHEMBL15535835 | 0.70 | TNKS (1.00) | TNKSTNKS2 | |
| SCHEMBL15534915 | 0.70 | TNKS (1.00) | TNKSTNKS2 | |
| SCHEMBL11949875 | 0.68 | TNKS (0.51) | TNKSTNKS2LMNAPOLBHPGD | |
| SCHEMBL11949643 | 0.68 | MAPT (0.51) | TNKSTNKS2MEN1LMNAPOLB | |
| SCHEMBL1554562 | 0.67 | ALDH1A1 (0.54) | TNKSTNKS2LMNAKMT2ATDP1 | |
| SCHEMBL1554563 | 0.67 | ALDH1A1 (0.54) | TNKSTNKS2LMNAKMT2ATDP1 | |
| SCHEMBL15547007 | 0.67 | TNKS (0.64) | TNKSTNKS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013177349-A2 | QUINAZOLINEDIONES AS TANKYRASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2013-11-28 | — | — | WO | disclosed |