Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 8/20 | 1.00 |
| ▸ | TNKS2 | Q9H2K2 | 8/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15548554 | 0.84 | TNKS (1.00) | TNKSTNKS2MEN1POLBKMT2A | |
| SCHEMBL3869028 | 0.80 | TNKS (0.67) | TNKSTNKS2MEN1POLBKMT2A | |
| SCHEMBL15462269 | 0.76 | TNKS (0.61) | TNKSTNKS2MEN1POLBKMT2A | |
| SCHEMBL12549503 | 0.74 | TNKS (0.59) | TNKSTNKS2MEN1POLBKMT2A | |
| SCHEMBL15534915 | 0.73 | TNKS (1.00) | TNKSTNKS2 | |
| SCHEMBL15535835 | 0.73 | TNKS (1.00) | TNKSTNKS2 | |
| SCHEMBL12791230 | 0.73 | LMNA (0.72) | TNKSTNKS2MEN1POLBKMT2A | |
| SCHEMBL15547646 | 0.73 | TNKS (0.82) | TNKSTNKS2 | |
| SCHEMBL15547644 | 0.73 | TNKS (0.82) | TNKSTNKS2 | |
| SCHEMBL6520217 | 0.72 | KMT2A (0.71) | TNKSTNKS2MEN1POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9771351-B2 | Wnt signaling inhibitor | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2017-09-26 | — | — | US | disclosed |
| US-9771351-B2 | Wnt signaling inhibitor | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2017-09-26 | — | — | US | disclosed |
| US-20160168125-A1 | WNT SIGNALING INHIBITOR | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2016-06-16 | — | — | US | disclosed |
| US-20160168125-A1 | WNT SIGNALING INHIBITOR | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2016-06-16 | — | — | US | disclosed |
| EP-3028703-A1 | Wnt SIGNALING INHIBITOR | Kyowa Hakko Kirin Co., Ltd. (JP) | 2016-06-08 | — | — | EP | disclosed |
| US-20150374696-A1 | WNT PROTEIN SIGNALLING INHIBITORS | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2015-12-31 | — | — | US | disclosed |
| US-20150374696-A1 | WNT PROTEIN SIGNALLING INHIBITORS | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2015-12-31 | — | — | US | disclosed |
| US-9045416-B2 | WNT protein signalling inhibitors | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2015-06-02 | — | — | US | disclosed |
| US-9045416-B2 | WNT protein signalling inhibitors | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2015-06-02 | — | — | US | disclosed |
| WO-2015016195-A1 | Wnt SIGNALING INHIBITOR | 協和発酵キリン株式会社 (JP) | 2015-02-05 | — | — | WO | disclosed |
| US-20140255426-A1 | WNT PATHWAY INHIBITORS FOR TREATING VIRAL INFECTIONS | EMORY UNIVERSITY (US) | 2014-09-11 | — | — | US | disclosed |
| US-20140038922-A1 | WNT PROTEIN SIGNALLING INHIBITORS | UNIV TEXAS (US) | 2014-02-06 | — | — | US | disclosed |
| US-20140038922-A1 | WNT PROTEIN SIGNALLING INHIBITORS | UNIV TEXAS (US) | 2014-02-06 | — | — | US | disclosed |
| US-8445491-B2 | Wnt protein signalling inhibitors | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2013-05-21 | — | — | US | disclosed |
| US-8445491-B2 | Wnt protein signalling inhibitors | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2013-05-21 | — | — | US | disclosed |
| US-20110136813-A1 | WNT PROTEIN SIGNALLING INHIBITORS | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2011-06-09 | — | — | US | disclosed |
| US-20110136813-A1 | WNT PROTEIN SIGNALLING INHIBITORS | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2011-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140038922-A1 | WNT PROTEIN SIGNALLING INHIBITORS | WNT1, WNT3A, DKK1 | TNKS 2561/4885TNKS2 1132/4885MEN1 3251/4885 |
| US-20110136813-A1 | WNT PROTEIN SIGNALLING INHIBITORS | WNT1, WNT3A, DKK1 | TNKS 2561/4885TNKS2 1132/4885MEN1 3251/4885 |
| US-20150374696-A1 | WNT PROTEIN SIGNALLING INHIBITORS | WNT1, WNT3A, DKK1 | TNKS 2561/4885TNKS2 1132/4885MEN1 3251/4885 |
| US-20160168125-A1 | WNT SIGNALING INHIBITOR | WNT3A, WNT1, WNT3 | TNKS 3154/4885TNKS2 3216/4885MEN1 2633/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.