Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 2/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | PARP15 | Q460N3 | 2/20 | 0.36 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17709961 | 0.95 | HTR6 (0.35) | HTR6HPGDTP53RORCF2 | |
| SCHEMBL17709924 | 0.88 | HPGD (0.39) | HPGDTP53F2CNR1CNR2 | |
| SCHEMBL28005027 | 0.86 | HPGD (0.39) | HPGDTP53F2CNR1CNR2 | |
| SCHEMBL17709928 | 0.84 | KDM4E (0.36) | HPGDTP53F2CNR1CNR2 | |
| SCHEMBL17760503 | 0.81 | NPC1 (0.35) | HPGDTP53F2CNR1CNR2 | |
| SCHEMBL15537844 | 0.81 | ALDH1A1 (0.40) | HPGDTP53CNR1CNR2SMN1; SMN2 | |
| SCHEMBL5240161 | 0.80 | NPC1 (0.46) | HPGDTP53CNR1SMN1; SMN2RECQL | |
| SCHEMBL15537682 | 0.79 | SMN1; SMN2 (0.47) | HPGDCNR1CNR2SMN1; SMN2KDM4E | |
| SCHEMBL17710090 | 0.78 | MEN1 (0.35) | SMN1; SMN2MEN1ALDH1A1KMT2A | |
| SCHEMBL17710087 | 0.78 | MEN1 (0.35) | SMN1; SMN2MEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2855440-A1 | CARBOXAMIDE OR SULFONAMIDE SUBSTITUTED THIAZOLES AND RELATED DERIVATIVES AS MODULATORS FOR THE ORPHAN NUCLEAR RECEPTOR ROR[GAMMA] | Phenex Pharmaceuticals AG (DE) | 2015-04-08 | — | — | EP | disclosed |
| WO-2013178362-A1 | CARBOXAMIDE OR SULFONAMIDE SUBSTITUTED THIAZOLES AND RELATED DERIVATIVES AS MODULATORS FOR THE ORPHAN NUCLEAR RECEPTOR ROR[GAMMA] | PHENEX PHARMACEUTICALS AG (DE) | 2013-12-05 | — | — | WO | disclosed |