Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 7/20 | 0.71 |
| ▸ | CA2 | P00918 | 7/20 | 0.71 |
| ▸ | CA9 | Q16790 | 7/20 | 0.71 |
| ▸ | PTGS2 | P35354 | 11/20 | 0.59 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.59 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19759267 | 0.90 | PTGS2 (0.69) | CA1CA2CA9PTGS2PTGS1 | |
| SCHEMBL15552398 | 0.89 | PTGS2 (0.69) | CA1CA2CA9PTGS2PTGS1 | |
| SCHEMBL15550607 | 0.88 | CA1 (0.69) | CA1CA2CA9PTGS2PTGS1 | |
| SCHEMBL6531664 | 0.85 | PTGS2 (0.78) | CA1CA2CA9PTGS2PTGS1 | |
| SCHEMBL15552223 | 0.85 | CA1 (0.65) | CA1CA2CA9PTGS2PTGS1 | |
| SCHEMBL6531306 | 0.83 | CA9 (1.00) | CA1CA2CA9PTGS2PTGS1 | |
| SCHEMBL15559114 | 0.81 | CA1 (0.60) | CA1CA2CA9PTGS2PTGS1 | |
| SCHEMBL16807764 | 0.81 | CA1 (0.46) | CA1CA2CA9PTGS2PTGS1 | |
| SCHEMBL19759271 | 0.81 | CA1 (0.59) | CA1CA2CA9PTGS2PTGS1 | |
| SCHEMBL15551431 | 0.80 | CA1 (0.71) | CA1CA2CA9PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3406598-A1 | PYRAZOLE DERIVATIVES AS INHIBITORS OF STAT3 | Mayo Foundation for Medical Education and Research (US) | 2018-11-28 | — | — | EP | claimed |
| US-20150166484-A1 | PYRAZOLE DERIVATIVES AS INHIBITORS OF STAT3 | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH | 2015-06-18 | — | — | US | claimed |
| EP-2861562-A1 | PYRAZOLE DERIVATIVES AS INHIBITORS OF STAT3 | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2015-04-22 | — | — | EP | claimed |
| WO-2013187965-A1 | PYRAZOLE DERIVATIVES AS INHIBITORS OF STAT3 | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2013-12-19 | — | — | WO | claimed |
| EP-3406598-B1 | PYRAZOLE DERIVATIVES AS INHIBITORS OF STAT3 | MAYO FOUND MEDICAL EDUCATION & RES (US) | 2020-01-29 | — | — | EP | disclosed |
| EP-3406598-B1 | PYRAZOLE DERIVATIVES AS INHIBITORS OF STAT3 | MAYO FOUND MEDICAL EDUCATION & RES (US) | 2020-01-29 | — | — | EP | disclosed |
| EP-3406598-A1 | PYRAZOLE DERIVATIVES AS INHIBITORS OF STAT3 | Mayo Foundation for Medical Education and Research (US) | 2018-11-28 | — | — | EP | disclosed |
| US-10138208-B2 | Pyrazole derivatives as inhibitors of STAT3 | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2018-11-27 | — | — | US | disclosed |
| EP-2861562-B1 | PYRAZOLE DERIVATIVES AS INHIBITORS OF STAT3 | MAYO FOUND MEDICAL EDUCATION & RES (US) | 2018-05-09 | — | — | EP | disclosed |
| US-20180002290-A1 | PYRAZOLE DERIVATIVES AS INHIBITORS OF STAT3 | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2018-01-04 | — | — | US | disclosed |
| US-9732038-B2 | Pyrazole derivatives as inhibitors of STAT3 | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2017-08-15 | — | — | US | disclosed |
| US-9732038-B2 | Pyrazole derivatives as inhibitors of STAT3 | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2017-08-15 | — | — | US | disclosed |
| US-20150166484-A1 | PYRAZOLE DERIVATIVES AS INHIBITORS OF STAT3 | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH | 2015-06-18 | — | — | US | disclosed |
| US-20150166484-A1 | PYRAZOLE DERIVATIVES AS INHIBITORS OF STAT3 | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH | 2015-06-18 | — | — | US | disclosed |
| EP-2861562-A1 | PYRAZOLE DERIVATIVES AS INHIBITORS OF STAT3 | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2015-04-22 | — | — | EP | disclosed |
| WO-2013187965-A1 | PYRAZOLE DERIVATIVES AS INHIBITORS OF STAT3 | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2013-12-19 | — | — | WO | disclosed |
| US-20090291212-A1 | VOLATILE METAL COMPLEXES OF PERFLUORO-tert-BUTANOL | SYRACUSE UNIVERSITY (US) | 2009-11-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10138208-B2 | Pyrazole derivatives as inhibitors of STAT3 | STAT3, STAT6, JAK2 | CA1 4137/4885CA2 3692/4885CA9 3507/4885 |
| US-20180002290-A1 | PYRAZOLE DERIVATIVES AS INHIBITORS OF STAT3 | STAT3, STAT6, JAK2 | CA1 4137/4885CA2 3692/4885CA9 3507/4885 |
| US-20150166484-A1 | PYRAZOLE DERIVATIVES AS INHIBITORS OF STAT3 | STAT3, STAT6, JAK2 | CA1 4137/4885CA2 3692/4885CA9 3507/4885 |
| US-20090291212-A1 | VOLATILE METAL COMPLEXES OF PERFLUORO-tert-BUTANOL | JUND, NONO, VAPA | CA1 3174/4885CA2 2010/4885CA9 1796/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.