Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3727342 | 0.78 | TSHR (0.56) | TSHRALDH1A1MAPTGFERHDAC1 | |
| SCHEMBL17033022 | 0.75 | TSHR (0.58) | TSHRALDH1A1MAPTGFERHDAC1 | |
| SCHEMBL20069785 | 0.74 | TSHR (0.51) | TSHRALDH1A1SMN1; SMN2MAPTGFER | |
| SCHEMBL1841619 | 0.73 | GPR132 (0.64) | TSHRALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL27761582 | 0.71 | TSHR (0.55) | TSHRALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL22857001 | 0.71 | TSHR (0.48) | TSHRALDH1A1RAB9AHDAC1HDAC6 | |
| SCHEMBL20147988 | 0.71 | THRB (0.49) | TSHRALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL20147648 | 0.71 | TSHR (0.48) | TSHRALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1840374 | 0.70 | GPR132 (0.52) | TSHRALDH1A1SMN1; SMN2MAPTHDAC1 | |
| SCHEMBL17133479 | 0.69 | TSHR (0.59) | TSHRALDH1A1SMN1; SMN2MAPTGFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2861566-A1 | NEW DIAZASPIROCYCLOALKANE AND AZASPIROCYCLOALKANE | F. Hoffmann-La Roche AG (CH) | 2015-04-22 | — | — | EP | disclosed |
| WO-2013186159-A1 | NEW DIAZASPIROCYCLOALKANE AND AZASPIROCYCLOALKANE | F. HOFFMANN-LA ROCHE AG (CH) | 2013-12-19 | — | — | WO | disclosed |