Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.56 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.56 |
| ▸ | FAAH | O00519 | 1/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.52 |
| ▸ | THRA | P10827 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.46 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.46 |
| ▸ | SELL | P14151 | 2/20 | 0.46 |
| ▸ | SELP | P16109 | 2/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.44 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Desmethylflurbiprofen SCHEMBL538938 | 0.86 | PTGS1 (0.56) | AKR1C3AKR1C2FAAHPTGS2DGAT1 | |
| Desmethylflurbiprofen SCHEMBL239447 | 0.84 | PTGS1 (0.55) | AKR1C3AKR1C2FAAHPTGS2DGAT1 | |
| SCHEMBL15564511 | 0.83 | AKR1C3 (0.51) | AKR1C3AKR1C2FAAHPTGS2LMNA | |
| SCHEMBL4943055 | 0.83 | CA2 (0.56) | FAAHPTGS2THRATHRBDGAT1 | |
| Methane SCHEMBL11691361 | 0.82 | CA2 (0.55) | FAAHPTGS2THRATHRBDGAT1 | |
| SCHEMBL4945342 | 0.80 | CA2 (0.56) | DGAT1SOAT1AKR1B1LMNAGAA | |
| SCHEMBL3914326 | 0.79 | GRIA2 (0.59) | PTGS2THRATHRBAKR1B1LMNA | |
| SCHEMBL31225628 | 0.79 | GRIA2 (0.59) | PTGS2THRATHRBAKR1B1LMNA | |
| SCHEMBL6564239 | 0.78 | ABCC4 (0.69) | AKR1B1LMNAGAATSHRABCC4 | |
| SCHEMBL3642916 | 0.77 | AKR1C3 (0.59) | AKR1C3AKR1C2LMNAKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2880015-B1 | MULTITARGET FAAH AND COX INHIBITORS AND THERAPEUTICAL USES THEREOF | FOND ST ITALIANO TECNOLOGIA (IT) | 2017-09-27 | — | — | EP | disclosed |
| EP-2880015-A1 | MULTITARGET FAAH AND COX INHIBITORS AND THERAPEUTICAL USES THEREOF | Fondazione Istituto Italiano Di Tecnologia (IT) | 2015-06-10 | — | — | EP | disclosed |
| WO-2014023643-A1 | MULTITARGET FAAH AND COX INHIBITORS AND THERAPEUTICAL USES THEREOF | FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (IT) | 2014-02-13 | — | — | WO | disclosed |
| WO-2014023325-A1 | MULTITARGET FAAH AND COX INHIBITORS AND THERAPEUTICAL USES THEREOF | FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (IT) | 2014-02-13 | — | — | WO | disclosed |