Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.53 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | CASP7 | P55210 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4649667 | 0.82 | DAO (0.52) | DAOALDH1A1KDM4EHSD17B10PIN1 | |
| SCHEMBL10969986 | 0.82 | KDM4E (0.66) | DAOALDH1A1KDM4EHSD17B10PIN1 | |
| SCHEMBL1366351 | 0.81 | DAO (0.65) | DAOALDH1A1KDM4EHSD17B10PIN1 | |
| SCHEMBL12082628 | 0.78 | ALDH1A1 (0.61) | DAOALDH1A1KDM4EHSD17B10PIN1 | |
| SCHEMBL22223088 | 0.75 | DAO (0.58) | DAOALDH1A1KDM4EHSD17B10PIN1 | |
| SCHEMBL4649161 | 0.75 | ALDH1A1 (0.50) | DAOALDH1A1KDM4EHSD17B10PIN1 | |
| SCHEMBL16767844 | 0.71 | DAO (1.00) | DAOALDH1A1KDM4EHSD17B10PIN1 | |
| SCHEMBL16381141 | 0.70 | DAO (0.68) | DAOALDH1A1KDM4EHSD17B10PIN1 | |
| SCHEMBL10330642 | 0.70 | DAO (0.63) | DAOALDH1A1KDM4EHSD17B10PIN1 | |
| SCHEMBL10969990 | 0.70 | DAO (0.58) | DAOALDH1A1KDM4EHSD17B10PIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2882724-A1 | COMPOUNDS FOR USE IN THE TREATMENT OF DISORDERS THAT ARE AMELIORATED BY INHIBITION OF HDAC | IRBM - Science Park S.p.A. (IT) | 2015-06-17 | — | — | EP | disclosed |
| WO-2014023754-A1 | COMPOUNDS FOR USE IN THE TREATMENT OF DISORDERS THAT ARE AMELIORATED BY INHIBITION OF HDAC | IRBM - SCIENCE PARK S.P.A. (IT) | 2014-02-13 | — | — | WO | disclosed |