Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 5/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 7/20 | 0.37 |
| ▸ | XIAP | P98170 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1562735 | 0.85 | GAA (0.48) | RIPK1TRPV1ALDH1A1P2RX7 | |
| SCHEMBL1562675 | 0.85 | GAA (0.48) | RIPK1TRPV1ALDH1A1P2RX7 | |
| SCHEMBL3913865 | 0.80 | RIPK1 (0.46) | RIPK1TRPV1 | |
| SCHEMBL15565126 | 0.76 | RIPK1 (0.63) | RIPK1ALDH1A1 | |
| SCHEMBL19207856 | 0.76 | RIPK1 (0.63) | RIPK1ALDH1A1 | |
| SCHEMBL17332733 | 0.73 | FFAR1 (0.38) | TRPV1ALDH1A1P2RX7 | |
| SCHEMBL17332734 | 0.73 | FFAR1 (0.38) | TRPV1ALDH1A1P2RX7 | |
| SCHEMBL1562230 | 0.71 | GAA (0.51) | RIPK1 | |
| SCHEMBL1562231 | 0.71 | GAA (0.51) | RIPK1 | |
| SCHEMBL1561572 | 0.70 | GAA (0.50) | RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9394263-B2 | Substituted hetero-azepinones | F. HOFFMANN-LA ROCHE AG (CH) | 2016-07-19 | — | — | US | disclosed |
| US-20150361059-A1 | SUBSTITUTED HETERO-AZEPINONES | HOFFMAN-LA ROCHE INC. (US) | 2015-12-17 | — | — | US | disclosed |
| EP-2882725-A1 | SUBSTITUTED HETERO-AZEPINONES | F. Hoffmann-La Roche AG (CH) | 2015-06-17 | — | — | EP | disclosed |
| WO-2014023708-A1 | SUBSTITUTED HETERO-AZEPINONES | F. HOFFMANN-LA ROCHE AG (CH) | 2014-02-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150361059-A1 | SUBSTITUTED HETERO-AZEPINONES | CCNY, CCNE1, CCND3 | RIPK1 2747/4885TRPV1 4593/4885ALDH1A1 2459/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.