Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 5/20 | 0.47 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.40 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.40 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.40 |
| ▸ | GRIK5 | Q16478 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16968206 | 0.92 | DAO (0.54) | DAOGRIA1GRIA2GRIA4GRIK5 | |
| SCHEMBL15563882 | 0.92 | DAO (0.54) | DAOMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL15563574 | 0.88 | DAO (0.47) | DAOGRIA1GRIA2GRIA4GRIK5 | |
| SCHEMBL15564859 | 0.88 | DAO (0.47) | DAOGRIA1GRIA2GRIA4GRIK5 | |
| SCHEMBL15564357 | 0.86 | DAO (0.51) | DAOGRIA1GRIA2GRIA4GRIK5 | |
| SCHEMBL15563742 | 0.86 | DAO (0.49) | DAOGRIA1GRIA2GRIA4GRIK5 | |
| SCHEMBL15564345 | 0.85 | DAO (0.50) | DAOGRIA1GRIA2GRIA4GRIK5 | |
| SCHEMBL15564215 | 0.84 | DAO (0.56) | DAO | |
| SCHEMBL15563974 | 0.84 | DAO (0.56) | DAO | |
| SCHEMBL15564464 | 0.83 | DAO (0.52) | DAOGRIA1GRIA2GRIA4GRIK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014025993-A1 | INHIBITORS OF D-AMINO ACID OXIDASE | THE JOHNS HOPKINS UNIVERSITY (US) | 2014-02-13 | — | — | WO | disclosed |