Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 2/20 | 0.37 |
| ▸ | NAAA | Q02083 | 2/20 | 0.35 |
| ▸ | BCHE | P06276 | 4/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | MMP12 | P39900 | 1/20 | 0.32 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | FAAH | O00519 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27474261 | 0.94 | EPHX1 (0.44) | EPHX1NAAAHTTMMP2MMP9 | |
| SCHEMBL12292879 | 0.82 | EPHX1 (0.39) | EPHX1NAAABCHECHRM4CHRM5 | |
| SCHEMBL2220318 | 0.82 | KAT2B (0.36) | BCHECHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL31562747 | 0.78 | EPHX1 (0.37) | EPHX1NAAABCHECHRM4CHRM5 | |
| SCHEMBL14759201 | 0.77 | EPHX1 (0.44) | EPHX1NAAABCHECHRM4CHRM5 | |
| SCHEMBL5622283 | 0.76 | EPHX1 (0.47) | EPHX1NAAABCHEHTTMMP2 | |
| SCHEMBL13035727 | 0.75 | EPHX1 (0.35) | EPHX1NAAABCHECHRM4CHRM5 | |
| SCHEMBL15139547 | 0.75 | BCHE (0.58) | EPHX1NAAABCHEHTT | |
| SCHEMBL9863767 | 0.75 | EPHX1 (0.41) | EPHX1NAAAHTTMMP2MMP9 | |
| SCHEMBL23036780 | 0.75 | BTK (0.37) | EPHX1NAAABCHECHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104540807-B | For the method preparing pyrazole carboxylic acid derivant | 霍夫曼-拉罗奇有限公司 | 2016-09-14 | — | — | CN | claimed |
| EP-2885276-B1 | PROCESS FOR THE PREPARATION OF PYRAZOLE CARBOXYLIC ACID DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2016-06-01 | — | — | EP | claimed |
| US-9346763-B2 | Process for the preparation of pyrazole carboxylic acid derivatives | HOFFMAN-LA ROCHE INC. (US) | 2016-05-24 | — | — | US | claimed |
| EP-2885276-A1 | PROCESS FOR THE PREPARATION OF PYRAZOLE CARBOXYLIC ACID DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2015-06-24 | — | — | EP | claimed |
| US-20150158818-A1 | PROCESS FOR THE PREPARATION OF PYRAZOLE CARBOXYLIC ACID DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2015-06-11 | — | — | US | claimed |
| CN-104540807-A | Process for the preparation of pyrazole carboxylic acid derivatives | HOFFMANN LA ROCHE | 2015-04-22 | — | — | CN | claimed |
| WO-2014027009-A1 | PROCESS FOR THE PREPARATION OF PYRAZOLE CARBOXYLIC ACID DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2014-02-20 | — | — | WO | claimed |
| CN-104540807-B | For the method preparing pyrazole carboxylic acid derivant | 霍夫曼-拉罗奇有限公司 | 2016-09-14 | — | — | CN | disclosed |
| EP-2885276-B1 | PROCESS FOR THE PREPARATION OF PYRAZOLE CARBOXYLIC ACID DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2016-06-01 | — | — | EP | disclosed |
| US-9346763-B2 | Process for the preparation of pyrazole carboxylic acid derivatives | HOFFMAN-LA ROCHE INC. (US) | 2016-05-24 | — | — | US | disclosed |
| EP-2885276-A1 | PROCESS FOR THE PREPARATION OF PYRAZOLE CARBOXYLIC ACID DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2015-06-24 | — | — | EP | disclosed |
| US-20150158818-A1 | PROCESS FOR THE PREPARATION OF PYRAZOLE CARBOXYLIC ACID DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2015-06-11 | — | — | US | disclosed |
| CN-104540807-A | Process for the preparation of pyrazole carboxylic acid derivatives | HOFFMANN LA ROCHE | 2015-04-22 | — | — | CN | disclosed |
| WO-2014027009-A1 | PROCESS FOR THE PREPARATION OF PYRAZOLE CARBOXYLIC ACID DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2014-02-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150158818-A1 | PROCESS FOR THE PREPARATION OF PYRAZOLE CARBOXYLIC ACID DERIVATIVES | PDE10A, PDE3A, PDE5A | EPHX1 949/4885NAAA 458/4885BCHE 1002/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.