Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 3/20 | 0.41 |
| ▸ | FPR2 | P25090 | 2/20 | 0.39 |
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | PRKACA | P17612 | 1/20 | 0.37 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16902878 | 0.86 | CYP1A2 (0.50) | IKBKBDDB1CRBNFPR2PROKR1 | |
| SCHEMBL30477858 | 0.86 | CYP1A2 (0.50) | IKBKBDDB1CRBNFPR2PROKR1 | |
| SCHEMBL15553266 | 0.85 | APP (0.38) | IKBKBAPPCYP2C9PDK2CYP2A6 | |
| SCHEMBL15553267 | 0.85 | APP (0.38) | IKBKBAPPCYP2C9PDK2CYP2A6 | |
| SCHEMBL2454709 | 0.84 | APP (0.40) | IKBKBAPPCYP2C9PDK2CYP2A6 | |
| SCHEMBL15550388 | 0.84 | APP (0.40) | IKBKBAPPCYP2C9PDK2CYP2A6 | |
| SCHEMBL15553228 | 0.84 | APP (0.38) | IKBKBAPPCYP2C9PDK2ENPP2 | |
| SCHEMBL15552516 | 0.82 | FAAH (0.40) | IKBKBAPPCYP2C9PDK2CYP2A6 | |
| SCHEMBL15552512 | 0.82 | FAAH (0.40) | IKBKBAPPCYP2C9PDK2CYP2A6 | |
| SCHEMBL16860082 | 0.82 | ENPP2 (0.39) | APPCYP2C9PDK2ENPP2SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2879673-A1 | COMPOUNDS THAT ARE S1P MODULATING AGENTS AND/OR ATX MODULATING AGENTS | Biogen Idec MA Inc. (US) | 2015-06-10 | — | — | EP | disclosed |
| WO-2014025709-A1 | COMPOUNDS THAT ARE S1P MODULATING AGENTS AND/OR ATX MODULATING AGENTS | BIOGEN IDEC MA INC. (US) | 2014-02-13 | — | — | WO | disclosed |