Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | NPY1R | P25929 | 1/20 | 0.37 |
| ▸ | NPY2R | P49146 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.33 |
| ▸ | CDK2 | P24941 | 3/20 | 0.33 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15567088 | 0.87 | MAPT (0.38) | MAPTMEN1KMT2AALDH1A1GRM5 | |
| SCHEMBL15566545 | 0.78 | GRM5 (0.41) | MEN1KMT2AALDH1A1GRM5CCNA2 | |
| SCHEMBL4001733 | 0.75 | SMN1; SMN2 (0.52) | SMN1; SMN2MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL6381151 | 0.75 | HPGD (0.38) | SMN1; SMN2MEN1KMT2AALDH1A1HTT | |
| SCHEMBL16833262 | 0.74 | MAPT (0.53) | SMN1; SMN2MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL6381472 | 0.73 | HPGD (0.34) | SMN1; SMN2MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL6200618 | 0.71 | SMN1; SMN2 (0.50) | SMN1; SMN2MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL6690449 | 0.71 | SMN1; SMN2 (0.43) | SMN1; SMN2MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL6366582 | 0.69 | HCAR2 (0.39) | SMN1; SMN2MAPTMEN1KMT2ACDK2 | |
| SCHEMBL6994179 | 0.69 | MEN1 (0.49) | SMN1; SMN2MAPTMEN1KMT2APKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014024125-A1 | PYRAZOLO[4,3-D]PYRIMIDIN-7(6H)-ONE DERIVATIVES AS PDE9 INHIBITORS | CELON PHARMA S.A. (PL) | 2014-02-13 | — | — | WO | disclosed |