Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | UMPS | P11172 | 1/20 | 0.32 |
| ▸ | PDE5A | O76074 | 1/20 | 0.30 |
| ▸ | PDE1A | P54750 | 1/20 | 0.30 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.30 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.30 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.30 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 2/20 | 0.30 |
| ▸ | NOS3 | P29474 | 1/20 | 0.30 |
| ▸ | NOS1 | P29475 | 1/20 | 0.30 |
| ▸ | NOS2 | P35228 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27586435 | 0.85 | HPGD (0.39) | MAPTSMN1; SMN2HPGDPDE5APDE1A | |
| SCHEMBL15565941 | 0.76 | UMPS (0.35) | MAPTSMN1; SMN2UMPSPDE5APDE1A | |
| SCHEMBL29169668 | 0.73 | KDM4E (0.34) | MAPTSMN1; SMN2HTTKDM4EMEN1 | |
| SCHEMBL4038271 | 0.71 | MAPT (0.38) | MAPTSMN1; SMN2HPGDHTTCYP1A2 | |
| SCHEMBL6689894 | 0.71 | HCAR2 (0.39) | MAPTSMN1; SMN2HPGDHTTCYP1A2 | |
| SCHEMBL6848554 | 0.71 | HTT (0.40) | MAPTSMN1; SMN2HPGDHTTHSP90AA1 | |
| SCHEMBL4001733 | 0.69 | SMN1; SMN2 (0.52) | MAPTSMN1; SMN2CYP1A2MEN1KMT2A | |
| SCHEMBL1527741 | 0.68 | SMN1; SMN2 (0.41) | MAPTSMN1; SMN2HPGDHTTKDM4E | |
| SCHEMBL5243766 | 0.68 | ABCC8 (0.36) | MAPTSMN1; SMN2HTTKDM4EALDH1A1 | |
| SCHEMBL4043569 | 0.68 | KDM4E (0.34) | MAPTSMN1; SMN2HPGDHTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014024125-A1 | PYRAZOLO[4,3-D]PYRIMIDIN-7(6H)-ONE DERIVATIVES AS PDE9 INHIBITORS | CELON PHARMA S.A. (PL) | 2014-02-13 | — | — | WO | disclosed |