SCHEMBL15567155

SCHEMBL15567155

O=C(Cc1ccccc1)NC1CCN(c2nc3ccccc3n2Cc2cccc(F)c2)CC1

nearest known ligand 0.65

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 10/20 0.65
CYP2D6 P10635 4/20 0.56
HRH1 P35367 4/20 0.56
CHRM1 P11229 2/20 0.56
CCR3 P51677 2/20 0.56
PKM P14618 1/20 0.53
TSHR P16473 1/20 0.53
KCNH2 Q12809 2/20 0.50
MEN1 O00255 1/20 0.50
ALDH1A1 P00352 1/20 0.50
UBE2N P61088 1/20 0.50
KMT2A Q03164 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.50
TP53 P04637 1/20 0.49
MAPT P10636 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15568307 0.88 KMT2A (0.59) SIGMAR1CYP2D6HRH1CHRM1CCR3
SCHEMBL15568544 0.86 CYP2D6 (0.54) SIGMAR1CYP2D6HRH1CHRM1KCNH2
SCHEMBL31633065 0.85 HRH1 (0.55) SIGMAR1CYP2D6HRH1CHRM1TSHR
SCHEMBL15568581 0.83 HRH1 (0.49) SIGMAR1CYP2D6HRH1CHRM1KCNH2
SCHEMBL15569414 0.83 HRH1 (0.56) CYP2D6HRH1CHRM1TSHRKCNH2
SCHEMBL15568583 0.83 SIGMAR1 (0.50) SIGMAR1CYP2D6HRH1CHRM1KCNH2
SCHEMBL31633134 0.83 HRH1 (0.57) CYP2D6HRH1CHRM1TSHRKCNH2
SCHEMBL15569117 0.82 MEN1 (0.48) SIGMAR1CYP2D6HRH1CHRM1MEN1
SCHEMBL10337607 0.81 HRH1 (0.74) CYP2D6HRH1CHRM1KCNH2
SCHEMBL15568201 0.81 HRH1 (0.54) CYP2D6HRH1CHRM1TSHRKCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2014027053-A1 BENZIMIDAZOLES FOR THE TREATMENT OF CANCER MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) 2014-02-20 WO claimed
WO-2014027053-A1 BENZIMIDAZOLES FOR THE TREATMENT OF CANCER MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) 2014-02-20 WO disclosed