Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 2/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.49 |
| ▸ | PLK4 | O00444 | 1/20 | 0.49 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.49 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.49 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.49 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.49 |
| ▸ | PIM1 | P11309 | 1/20 | 0.49 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.49 |
| ▸ | PRKACA | P17612 | 1/20 | 0.49 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.49 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.49 |
| ▸ | CLK2 | P49760 | 1/20 | 0.49 |
| ▸ | GSK3A | P49840 | 1/20 | 0.49 |
| ▸ | PRKX | P51817 | 1/20 | 0.49 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.49 |
| ▸ | STK3 | Q13188 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3646839 | 0.93 | PLK4 (0.54) | ROCK2MAP4K4CLK4MKNK2PLK4 | |
| SCHEMBL28946669 | 0.91 | NAPRT (0.46) | CDC7 | |
| SCHEMBL7143112 | 0.83 | PLK4 (0.49) | ROCK2MAP4K4CLK4MKNK2PLK4 | |
| SCHEMBL27193240 | 0.81 | CHUK (0.55) | ROCK2MAP4K4CLK4MKNK2PLK4 | |
| SCHEMBL27214460 | 0.79 | BCAT2 (0.63) | PARP1IKBKBJAK2BCAT2KEAP1 | |
| SCHEMBL27341171 | 0.79 | PKN1 (0.52) | PKN1PKN2 | |
| SCHEMBL27193217 | 0.78 | CHUK (0.61) | ROCK2MAP4K4CLK4MKNK2PIM1 | |
| SCHEMBL15567698 | 0.77 | IKBKB (0.48) | ROCK2MAP4K4CLK4MKNK2PLK4 | |
| SCHEMBL28595822 | 0.77 | TTR (0.56) | PARP1BCAT2KEAP1NFE2L2 | |
| SCHEMBL27704997 | 0.76 | BCAT2 (0.59) | MKNK2PARP1IKBKBBCAT2KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014025651-A1 | CHROMAN DERIVATIVES AS TRPM8 INHIBITORS | AMGEN INC. (US) | 2014-02-13 | — | — | WO | disclosed |