Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 3/20 | 0.48 |
| ▸ | CHUK | O15111 | 3/20 | 0.48 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.48 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.48 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.47 |
| ▸ | HNF4A | P41235 | 1/20 | 0.45 |
| ▸ | CCNC | P24863 | 4/20 | 0.44 |
| ▸ | CDK8 | P49336 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.43 |
| ▸ | PRKACA | P17612 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL570758 | 0.86 | BCAT2 (0.63) | BCAT2HNF4AALDH1A1SRCPARP1 | |
| SCHEMBL29916354 | 0.86 | BCAT2 (0.63) | BCAT2HNF4AALDH1A1SRCPARP1 | |
| SCHEMBL867477 | 0.81 | MYC (0.47) | BCAT2HNF4AALDH1A1PARP1MYC | |
| SCHEMBL28115051 | 0.80 | IKBKB (0.54) | IKBKBCHUKIKBKEPKMYT1BCAT2 | |
| SCHEMBL15903687 | 0.80 | CCNC (0.50) | BCAT2CCNCCDK8ALDH1A1PIM1 | |
| Ethylamine SCHEMBL29028660 | 0.79 | BCAT2 (0.54) | BCAT2HNF4AALDH1A1MYCSMN1; SMN2 | |
| SCHEMBL6794827 | 0.79 | ALDH1A1 (0.60) | IKBKBCHUKIKBKEPKMYT1BCAT2 | |
| SCHEMBL8109600 | 0.78 | HNF4A (0.49) | IKBKBCHUKIKBKEPKMYT1HNF4A | |
| SCHEMBL901580 | 0.78 | BCAT2 (0.71) | IKBKBCHUKIKBKEPKMYT1BCAT2 | |
| SCHEMBL164881 | 0.78 | BCAT2 (0.71) | IKBKBCHUKIKBKEPKMYT1BCAT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014025651-A1 | CHROMAN DERIVATIVES AS TRPM8 INHIBITORS | AMGEN INC. (US) | 2014-02-13 | — | — | WO | disclosed |