Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | APP | P05067 | 11/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.35 |
| ▸ | DUT | P33316 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6182632 | 0.77 | TP53 (0.46) | TSHRKDM4EMAPK1TDP1MAPT | |
| SCHEMBL5312200 | 0.77 | CYSLTR2 (0.53) | TSHR | |
| SCHEMBL2552420 | 0.75 | MAOB (0.44) | KMT2ASMN1; SMN2 | |
| SCHEMBL16432400 | 0.73 | MAOB (0.57) | KDM4EKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL22491503 | 0.73 | MAOB (0.53) | APPKDM4EMAPK1TDP1KMT2A | |
| SCHEMBL15567141 | 0.72 | ALDH1A1 (0.44) | APPKDM4EKMT2ANPC1MAPT | |
| SCHEMBL6988479 | 0.72 | DRD1 (0.49) | TDP1MEN1KMT2ANPC1MAPT | |
| SCHEMBL380929 | 0.71 | CHRM2 (0.49) | ALDH1A1 | |
| SCHEMBL2420284 | 0.71 | SLC22A12 (0.42) | TDP1KMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL21495026 | 0.71 | CHRM2 (0.42) | TSHRMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2885306-A1 | IMIDAZO[2,1]THIAZOL-3-ONE DERIVATIVES USEFUL AS DIAGNOSTIC AGENTS FOR ALZHEIMER'S DISEASE | F. Hoffmann-La Roche AG (CH) | 2015-06-24 | — | — | EP | disclosed |
| WO-2014026881-A1 | IMIDAZO[2,1]THIAZOL-3-ONE DERIVATIVES USEFUL AS DIAGNOSTIC AGENTS FOR ALZHEIMER'S DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2014-02-20 | — | — | WO | disclosed |