Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.35 |
| ▸ | APP | P05067 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.34 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31371989 | 0.77 | ALDH1A1 (0.75) | ALDH1A1SMN1; SMN2HTTHPGDKMT2A | |
| SCHEMBL2235033 | 0.77 | KDM4E (0.49) | ALDH1A1SMN1; SMN2HTTHPGDKMT2A | |
| SCHEMBL11734033 | 0.75 | CYSLTR2 (0.51) | ALDH1A1KMT2ALMNAKDM4EL3MBTL1 | |
| SCHEMBL19463206 | 0.74 | CCNB2 (0.51) | ALDH1A1SMN1; SMN2PTK2BLMNAKDM4E | |
| SCHEMBL6618757 | 0.74 | CCNB2 (0.51) | ALDH1A1SMN1; SMN2PTK2BLMNAKDM4E | |
| SCHEMBL15568624 | 0.72 | TSHR (0.39) | ALDH1A1SMN1; SMN2KMT2AKDM4ENPC1 | |
| SCHEMBL169082 | 0.71 | CA1 (0.46) | ALDH1A1HTTKMT2AKDM4EPOLB | |
| SCHEMBL5608059 | 0.69 | KCNK3 (0.38) | ALDH1A1KDM4EPOLBL3MBTL1CYP2D6 | |
| SCHEMBL7926214 | 0.69 | ALDH1A1 (0.88) | ALDH1A1SMN1; SMN2HTTHPGDKMT2A | |
| SCHEMBL7927335 | 0.69 | ALDH1A1 (0.88) | ALDH1A1SMN1; SMN2HTTHPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2885306-A1 | IMIDAZO[2,1]THIAZOL-3-ONE DERIVATIVES USEFUL AS DIAGNOSTIC AGENTS FOR ALZHEIMER'S DISEASE | F. Hoffmann-La Roche AG (CH) | 2015-06-24 | — | — | EP | disclosed |
| WO-2014026881-A1 | IMIDAZO[2,1]THIAZOL-3-ONE DERIVATIVES USEFUL AS DIAGNOSTIC AGENTS FOR ALZHEIMER'S DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2014-02-20 | — | — | WO | disclosed |