Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT4 | P35916 | 8/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 3/20 | 0.37 |
| ▸ | ITK | Q08881 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.35 |
| ▸ | RPS6KA1 | Q15418 | 3/20 | 0.35 |
| ▸ | STAT6 | P42226 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | NPR3 | P17342 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15568784 | 0.91 | FLT4 (0.43) | FLT4KDRMAPK1RPS6KA1CYP3A4 | |
| SCHEMBL15513626 | 0.86 | FLT4 (0.46) | FLT4KDREGFRITKMAPK1 | |
| SCHEMBL15513711 | 0.78 | FLT4 (0.49) | FLT4KDRMAPK1RPS6KA1NPR3 | |
| SCHEMBL15513029 | 0.78 | FLT4 (0.52) | FLT4KDRMAPK1RPS6KA1 | |
| SCHEMBL15568714 | 0.76 | FLT4 (0.76) | FLT4KDR | |
| SCHEMBL15512843 | 0.73 | FLT4 (0.62) | FLT4KDRMAPK1RPS6KA1CYP3A4 | |
| SCHEMBL15512828 | 0.73 | FLT4 (0.49) | FLT4KDR | |
| SCHEMBL15512982 | 0.72 | FLT4 (0.51) | FLT4KDR | |
| SCHEMBL15568781 | 0.71 | FLT4 (0.76) | FLT4KDR | |
| SCHEMBL15512829 | 0.71 | FLT4 (0.49) | FLT4KDREGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2885291-A1 | VEGFR3 INHIBITORS | Cancer Therapeutics Crc Pty Limited (AU) | 2015-06-24 | — | — | EP | disclosed |
| WO-2014026243-A1 | VEGFR3 INHIBITORS | CANCER THERAPEUTICS CRC PTY LIMITED (AU) | 2014-02-20 | — | — | WO | disclosed |