Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT4 | P35916 | 16/20 | 0.43 |
| ▸ | KDR | P35968 | 4/20 | 0.43 |
| ▸ | NPR3 | P17342 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15568716 | 0.91 | FLT4 (0.43) | FLT4KDRNPR3CYP3A4CYP2C8 | |
| SCHEMBL15513711 | 0.85 | FLT4 (0.49) | FLT4KDRNPR3PTK2MAPK1 | |
| SCHEMBL15513626 | 0.77 | FLT4 (0.46) | FLT4KDRNPR3MAPK1RPS6KA1 | |
| SCHEMBL15513472 | 0.77 | FLT4 (0.49) | FLT4KDRPTK2 | |
| SCHEMBL15568781 | 0.76 | FLT4 (0.76) | FLT4KDR | |
| SCHEMBL15513211 | 0.76 | FLT4 (0.48) | FLT4KDRPTK2 | |
| SCHEMBL15513029 | 0.76 | FLT4 (0.52) | FLT4KDRPTK2MAPK1RPS6KA1 | |
| SCHEMBL15513429 | 0.74 | FLT4 (0.48) | FLT4KDR | |
| SCHEMBL15513122 | 0.74 | FLT4 (0.50) | FLT4KDRPTK2 | |
| SCHEMBL15513065 | 0.73 | FLT4 (0.49) | FLT4KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2885291-A1 | VEGFR3 INHIBITORS | Cancer Therapeutics Crc Pty Limited (AU) | 2015-06-24 | — | — | EP | disclosed |
| WO-2014026243-A1 | VEGFR3 INHIBITORS | CANCER THERAPEUTICS CRC PTY LIMITED (AU) | 2014-02-20 | — | — | WO | disclosed |