Known targets — ChEMBL curated mechanism
SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9A
The experimentally established mechanism targets of Lidocaine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN3A known ✓ | Q9NY46 | 2/20 | 0.59 |
| ▸ | SCN4A known ✓ | P35499 | 1/20 | 0.59 |
| ▸ | SCN5A known ✓ | Q14524 | 1/20 | 0.59 |
| ▸ | SCN9A known ✓ | Q15858 | 1/20 | 0.59 |
| ▸ | SCN1A known ✓ | P35498 | 1/20 | 0.41 |
| ▸ | SCN2A known ✓ | Q99250 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 5/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | MC4R | P32245 | 1/20 | 0.59 |
| ▸ | MC3R | P41968 | 1/20 | 0.59 |
| ▸ | HTR3A | P46098 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 3/20 | 0.58 |
| ▸ | BLM | P54132 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aptocaine SCHEMBL246792 | 0.82 | ATM (0.71) | ATMMAPTALDH1A1SCN3ASMN1; SMN2 | |
| Aptocaine SCHEMBL246793 | 0.82 | ATM (0.71) | ATMMAPTALDH1A1SCN3ASMN1; SMN2 | |
| Aptocaine SCHEMBL29417821 | 0.82 | ATM (0.71) | ATMMAPTALDH1A1SCN3ASMN1; SMN2 | |
| Lidocaine SCHEMBL2019133 | 0.79 | SCN3A (0.70) | MAPTLMNAALDH1A1SCN3ACYP3A4 | |
| SCHEMBL18485508 | 0.78 | ATM (1.00) | ATMLMNAALDH1A1CYP3A4SMN1; SMN2 | |
| SCHEMBL22746436 | 0.77 | ATM (0.97) | ATMALDH1A1CYP3A4SMN1; SMN2NPC1 | |
| SCHEMBL18486453 | 0.77 | ATM (0.97) | ATMALDH1A1CYP3A4SMN1; SMN2NPC1 | |
| Lidocaine SCHEMBL8183082 | 0.77 | MAPT (1.00) | MAPTLMNAALDH1A1SCN3ACYP3A4 | |
| Lidocaine SCHEMBL5334354 | 0.77 | MAPT (1.00) | MAPTLMNAALDH1A1SCN3ACYP3A4 | |
| Lidocaine SCHEMBL15689 | 0.77 | MAPT (1.00) | MAPTLMNAALDH1A1SCN3ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014027006-A1 | BIOADHESIVE FORMULATIONS FOR USE IN DRUG DELIVERY | EDKO PAZARLAMA TANITIM TICARET LIMITED SIRKETI (TR) | 2014-02-20 | — | — | WO | disclosed |