Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 4/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.48 |
| ▸ | CHRNG | P07510 | 1/20 | 0.48 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.48 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.48 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.48 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18486453 | 0.98 | ATM (0.97) | ATMSMN1; SMN2POLBMEN1KMT2A | |
| SCHEMBL22746436 | 0.98 | ATM (0.97) | ATMSMN1; SMN2POLBMEN1KMT2A | |
| SCHEMBL10837199 | 0.87 | ATM (0.76) | ATMSMN1; SMN2POLBMEN1KMT2A | |
| SCHEMBL7431865 | 0.87 | ATM (0.76) | ATMSMN1; SMN2POLBMEN1KMT2A | |
| SCHEMBL10356576 | 0.86 | ATM (0.74) | ATMSMN1; SMN2POLBMEN1KMT2A | |
| Aptocaine SCHEMBL29417821 | 0.83 | ATM (0.71) | ATMSMN1; SMN2MEN1KMT2ANPSR1 | |
| Aptocaine SCHEMBL246793 | 0.83 | ATM (0.71) | ATMSMN1; SMN2MEN1KMT2ANPSR1 | |
| Aptocaine SCHEMBL246792 | 0.83 | ATM (0.71) | ATMSMN1; SMN2MEN1KMT2ANPSR1 | |
| SCHEMBL18485512 | 0.81 | ATM (0.68) | ATMPOLBMEN1KMT2ACYP3A4 | |
| SCHEMBL18485516 | 0.80 | ATM (0.66) | ATMPOLBMEN1KMT2ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11021443-B2 | Charged ion channel blockers and methods for use | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2021-06-01 | — | — | US | disclosed |
| US-20200377459-A1 | CHARGED ION CHANNEL BLOCKERS AND METHODS FOR USE | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2020-12-03 | — | — | US | disclosed |
| WO-2017024037-A1 | CHARGED ION CHANNEL BLOCKERS AND METHODS FOR USE | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2017-02-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200377459-A1 | CHARGED ION CHANNEL BLOCKERS AND METHODS FOR USE | TRPV1, TRPV2, TRPA1 | ATM 4664/4885SMN1; SMN2 2744/4885POLB 1938/4885 |
| US-11021443-B2 | Charged ion channel blockers and methods for use | TRPV1, TRPV2, TRPA1 | ATM 4664/4885SMN1; SMN2 2744/4885POLB 1938/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.