Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 6/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | PDE6D | O43924 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.49 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL15568270 | 0.91 | MAPT (0.57) | MAPTHTTTP53MEN1KMT2A | |
| Trifluoroacetic Acid SCHEMBL15569280 | 0.90 | MAPT (0.57) | MAPTHTTTP53PDE6DALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL15568118 | 0.89 | MAPT (0.55) | MAPTHTTTP53MEN1KMT2A | |
| Trifluoroacetic Acid SCHEMBL15568526 | 0.85 | MAPT (0.58) | MAPTTP53PDE6DALDH1A1ALDH2 | |
| Trifluoroacetic Acid SCHEMBL15569243 | 0.85 | ALDH1A1 (0.58) | MAPTHTTTP53PDE6DALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL15568514 | 0.85 | SLC2A1 (0.52) | MAPTTP53PDE6DALDH1A1ALDH2 | |
| Trifluoroacetic Acid SCHEMBL15568177 | 0.83 | MAPT (0.49) | MAPTTP53KMT2APDE6DALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL15568649 | 0.81 | ALDH1A1 (0.57) | MAPTHTTTP53PDE6DALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL15568444 | 0.81 | LMNA (0.50) | MAPTTP53KMT2APDE6DALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL15569268 | 0.80 | MAPT (0.52) | MAPTTP53PDE6DALDH1A1ALDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014027053-A1 | BENZIMIDAZOLES FOR THE TREATMENT OF CANCER | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-02-20 | — | — | WO | claimed |
| WO-2014027053-A1 | BENZIMIDAZOLES FOR THE TREATMENT OF CANCER | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-02-20 | — | — | WO | disclosed |