Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 10/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 9/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.44 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | FNTA | P49354 | 1/20 | 0.38 |
| ▸ | FNTB | P49356 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2457390 | 0.75 | OPRD1 (0.61) | OPRD1OPRM1OPRK1KCNH2SETD7 | |
| Hydrochloric Acid SCHEMBL7647391 | 0.73 | OPRD1 (0.59) | OPRD1OPRM1OPRK1KCNH2SETD7 | |
| Bromide SCHEMBL10598951 | 0.73 | OPRD1 (0.59) | OPRD1OPRM1OPRK1KCNH2SETD7 | |
| SCHEMBL8313654 | 0.72 | OPRD1 (0.64) | OPRD1OPRM1OPRK1KCNH2SETD7 | |
| SCHEMBL22773372 | 0.71 | OPRD1 (0.49) | OPRD1OPRM1OPRK1KCNH2SETD7 | |
| SCHEMBL22491457 | 0.71 | OPRD1 (0.49) | OPRD1OPRM1OPRK1KCNH2SETD7 | |
| SCHEMBL29479614 | 0.69 | OPRD1 (0.44) | OPRD1OPRM1OPRK1KCNH2SETD7 | |
| SCHEMBL8316576 | 0.69 | OPRD1 (0.60) | OPRD1OPRM1OPRK1KCNH2SETD7 | |
| SCHEMBL28605586 | 0.69 | CYP2D6 (0.45) | CYP2D6KMT2AMEN1LMNAKDM4E | |
| SCHEMBL12751010 | 0.69 | OPRD1 (0.48) | OPRD1OPRM1OPRK1KCNH2SETD7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9505752-B2 | Piperidine amide derivatives as HIV attachment inhibitors | VIIV HEALTHCARE UK (NO. 5) LIMITED (GB) | 2016-11-29 | — | — | US | disclosed |
| US-9505752-B2 | Piperidine amide derivatives as HIV attachment inhibitors | VIIV HEALTHCARE UK (NO. 5) LIMITED (GB) | 2016-11-29 | — | — | US | disclosed |
| US-9505752-B2 | Piperidine amide derivatives as HIV attachment inhibitors | VIIV HEALTHCARE UK (NO. 5) LIMITED (GB) | 2016-11-29 | — | — | US | disclosed |
| EP-2895471-B1 | PIPERIDINE AMIDE DERIVATIVES AS HIV ATTACHMENT INHIBITORS | VIIV HEALTHCARE UK NO 5 LTD (GB) | 2016-11-23 | — | — | EP | disclosed |
| EP-2895471-B1 | PIPERIDINE AMIDE DERIVATIVES AS HIV ATTACHMENT INHIBITORS | VIIV HEALTHCARE UK NO 5 LTD (GB) | 2016-11-23 | — | — | EP | disclosed |
| US-20150210684-A1 | PIPERIDINE AMIDE DERIVATIVES AS HIV ATTACHMENT INHIBITORS | VIIV HEALTHCARE UK (NO. 5) LIMITED (GB) | 2015-07-30 | — | — | US | disclosed |
| US-20150210684-A1 | PIPERIDINE AMIDE DERIVATIVES AS HIV ATTACHMENT INHIBITORS | VIIV HEALTHCARE UK (NO. 5) LIMITED (GB) | 2015-07-30 | — | — | US | disclosed |
| US-20150210684-A1 | PIPERIDINE AMIDE DERIVATIVES AS HIV ATTACHMENT INHIBITORS | VIIV HEALTHCARE UK (NO. 5) LIMITED (GB) | 2015-07-30 | — | — | US | disclosed |
| EP-2895471-A1 | PIPERIDINE AMIDE DERIVATIVES AS HIV ATTACHMENT INHIBITORS | Bristol-Myers Squibb Company (US) | 2015-07-22 | — | — | EP | disclosed |
| WO-2014025854-A1 | PIPERIDINE AMIDE DERIVATIVES AS HIV ATTACHMENT INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-02-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150210684-A1 | PIPERIDINE AMIDE DERIVATIVES AS HIV ATTACHMENT INHIBITORS | CD4, HDAC5, ITGA5 | OPRD1 636/4885OPRM1 208/4885OPRK1 1049/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.