Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15569828 | 0.83 | SYK (0.67) | SYKJAK3 | |
| SCHEMBL15569438 | 0.82 | SYK (1.00) | SYK | |
| SCHEMBL15570037 | 0.73 | SYK (0.70) | SYKJAK3 | |
| SCHEMBL9465987 | 0.69 | CSNK2A2 (0.51) | — | |
| SCHEMBL15569702 | 0.68 | SYK (0.56) | SYKJAK3 | |
| SCHEMBL16765186 | 0.68 | JAK3 (1.00) | JAK3 | |
| SCHEMBL649678 | 0.68 | JAK3 (0.46) | SYKJAK3 | |
| SCHEMBL15569838 | 0.67 | SYK (1.00) | SYK | |
| SCHEMBL15569920 | 0.66 | SYK (0.74) | SYKJAK3 | |
| SCHEMBL2342183 | 0.66 | JAK3 (0.57) | JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2888262-A1 | PYRROLO[2,3-B]PYRAZINES AS SYK INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2015-07-01 | — | — | EP | disclosed |
| WO-2014029732-A1 | PYRROLO[2,3-B]PYRAZINES AS SYK INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2014-02-27 | — | — | WO | disclosed |