Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15569700 | 0.83 | SYK (0.69) | SYKJAK3 | |
| SCHEMBL15570037 | 0.81 | SYK (0.70) | SYKJAK3 | |
| SCHEMBL15569686 | 0.80 | SYK (1.00) | SYK | |
| SCHEMBL16765186 | 0.73 | JAK3 (1.00) | JAK3 | |
| SCHEMBL2342183 | 0.72 | JAK3 (0.57) | JAK3 | |
| SCHEMBL649678 | 0.71 | JAK3 (0.46) | SYKJAK3 | |
| SCHEMBL15569830 | 0.70 | SYK (0.45) | SYKJAK3 | |
| SCHEMBL25340759 | 0.70 | JAK3 (0.43) | JAK3 | |
| SCHEMBL29479536 | 0.70 | JAK3 (0.43) | JAK3 | |
| SCHEMBL650819 | 0.69 | JAK3 (0.47) | SYKJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2888262-A1 | PYRROLO[2,3-B]PYRAZINES AS SYK INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2015-07-01 | — | — | EP | disclosed |
| WO-2014029732-A1 | PYRROLO[2,3-B]PYRAZINES AS SYK INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2014-02-27 | — | — | WO | disclosed |