Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CUL4A | Q13619 | 5/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 14/20 | 0.64 |
| ▸ | MEN1 | O00255 | 13/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 13/20 | 0.64 |
| ▸ | MAPT | P10636 | 12/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 8/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.64 |
| ▸ | BRCA1 | P38398 | 5/20 | 0.64 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.64 |
| ▸ | USP2 | O75604 | 2/20 | 0.64 |
| ▸ | PRNP | P04156 | 2/20 | 0.64 |
| ▸ | HPGD | P15428 | 10/20 | 0.58 |
| ▸ | CASP1 | P29466 | 3/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | BLM | P54132 | 1/20 | 0.56 |
| ▸ | CASP7 | P55210 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15572548 | 0.81 | CUL4A (1.00) | CUL4AALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL15572874 | 0.77 | MEN1 (0.68) | CUL4AALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL21043625 | 0.77 | MEN1 (1.00) | CUL4AALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL10667172 | 0.73 | CUL4A (0.57) | CUL4AALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL15571632 | 0.69 | MEN1 (0.68) | CUL4AALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL15571479 | 0.69 | CUL4A (0.56) | CUL4AALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL21043628 | 0.68 | CUL4A (1.00) | CUL4AALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL15572039 | 0.66 | CUL4A (1.00) | CUL4AALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL6441000 | 0.64 | KMT2A (0.55) | CUL4AALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL15572213 | 0.64 | EEF2K (1.00) | CUL4AALDH1A1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104968323-B | CRL4 ubiquitin ligase inhibitors and uses thereof | 康奈尔大学 | 2020-08-21 | — | — | CN | claimed |
| US-10617683-B2 | Inhibitors of CRL4 ubiquitin ligase and uses thereof | CORNELL UNIVERSITY (US) | 2020-04-14 | — | — | US | claimed |
| US-20150196546-A1 | INHIBITORS OF CRL4 UBIQUITIN LIGASE AND USES THEREOF | CORNELL UNIVERSITY | 2015-07-16 | — | — | US | claimed |
| EP-2887940-A2 | INHIBITORS OF CRL4 UBIQUITIN LIGASE AND USES THEREOF | Cornell University (US) | 2015-07-01 | — | — | EP | claimed |
| WO-2014031759-A2 | INHIBITORS OF CRL4 UBIQUITIN LIGASE AND USES THEREOF | CORNELL UNIVERSITY (US) | 2014-02-27 | — | — | WO | claimed |
| CN-104968323-B | CRL4 ubiquitin ligase inhibitors and uses thereof | 康奈尔大学 | 2020-08-21 | — | — | CN | disclosed |
| US-10617683-B2 | Inhibitors of CRL4 ubiquitin ligase and uses thereof | CORNELL UNIVERSITY (US) | 2020-04-14 | — | — | US | disclosed |
| EP-2887940-B1 | INHIBITORS OF CRL4 UBIQUITIN LIGASE AND USES THEREOF | UNIV CORNELL (US) | 2019-06-05 | — | — | EP | disclosed |
| US-20150196546-A1 | INHIBITORS OF CRL4 UBIQUITIN LIGASE AND USES THEREOF | CORNELL UNIVERSITY | 2015-07-16 | — | — | US | disclosed |
| EP-2887940-A2 | INHIBITORS OF CRL4 UBIQUITIN LIGASE AND USES THEREOF | Cornell University (US) | 2015-07-01 | — | — | EP | disclosed |
| WO-2014031759-A2 | INHIBITORS OF CRL4 UBIQUITIN LIGASE AND USES THEREOF | CORNELL UNIVERSITY (US) | 2014-02-27 | — | — | WO | disclosed |