Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CUL4A | Q13619 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | MET | P08581 | 2/20 | 0.52 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.50 |
| ▸ | MAPT | P10636 | 8/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 4/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | GLA | P06280 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7817348 | 0.87 | MET (0.59) | CUL4ASMN1; SMN2POLBMAPK1MET | |
| SCHEMBL7815153 | 0.81 | KDM4E (0.60) | CUL4ASMN1; SMN2POLBMAPK1MET | |
| SCHEMBL7820657 | 0.81 | KDM4E (0.61) | SMN1; SMN2POLBMAPK1METRPS6KA3 | |
| SCHEMBL10663996 | 0.80 | ALDH1A1 (0.64) | SMN1; SMN2POLBMAPK1METRPS6KA3 | |
| SCHEMBL7814815 | 0.79 | ALDH1A1 (0.62) | SMN1; SMN2POLBMAPK1METRPS6KA3 | |
| SCHEMBL7817770 | 0.79 | MET (0.53) | SMN1; SMN2POLBMAPK1METRPS6KA3 | |
| SCHEMBL7814851 | 0.79 | ALDH1A1 (0.60) | SMN1; SMN2POLBMAPK1METRPS6KA3 | |
| SCHEMBL8928253 | 0.77 | PDE3B (0.52) | SMN1; SMN2POLBMAPK1METRPS6KA3 | |
| SCHEMBL7806871 | 0.76 | ALDH1A1 (0.53) | SMN1; SMN2POLBMAPK1METRPS6KA3 | |
| SCHEMBL7820367 | 0.76 | MET (0.50) | SMN1; SMN2POLBMAPK1METRPS6KA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4771057-A | TREATMENT OF ANGINA, ARRHYTHMIAS, CEREBRALVASCULAR DISEASE AND HYPERTENSION | UNIVERSITY OF ALBERTA (CA) | 1988-09-13 | — | — | US | disclosed |
| EP-0239186-A1 | Antihypertensive reduced pyridyl derivatives | The Governors of the University of Alberta (CA) | 1987-09-30 | — | — | EP | disclosed |