Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CUL4A | Q13619 | 5/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.54 |
| ▸ | GAA | P10253 | 4/20 | 0.54 |
| ▸ | ALPI | P09923 | 2/20 | 0.54 |
| ▸ | ALPG | P10696 | 2/20 | 0.54 |
| ▸ | ALPL | P05186 | 1/20 | 0.54 |
| ▸ | GLA | P06280 | 2/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 3/20 | 0.36 |
| ▸ | MAOB | P27338 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15572762 | 0.85 | CUL4A (1.00) | CUL4AKDM4EGAAALPIALPG | |
| SCHEMBL15570426 | 0.85 | CUL4A (1.00) | CUL4AKDM4EGAAALPIALPG | |
| SCHEMBL15572112 | 0.73 | CUL4A (1.00) | CUL4AKDM4EGAAALPIALPG | |
| SCHEMBL5333164 | 0.72 | CUL4A (0.78) | CUL4AKDM4EKMT2AALDH1A1POLB | |
| SCHEMBL10523341 | 0.70 | CUL4A (0.53) | CUL4AKDM4EGAAGLAGFER | |
| SCHEMBL21043638 | 0.69 | CUL4A (0.53) | CUL4AKDM4EGAAALPIALPG | |
| SCHEMBL15571481 | 0.69 | CUL4A (1.00) | CUL4AKDM4EGAAALPIALPG | |
| SCHEMBL17630172 | 0.68 | CUL4A (0.51) | CUL4AKDM4EGAAKMT2AALDH1A1 | |
| SCHEMBL6001543 | 0.68 | CUL4A (0.54) | CUL4AKDM4EGAAALPIALPG | |
| SCHEMBL21043636 | 0.68 | CUL4A (0.51) | CUL4AKDM4EGAAALPIALPG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2887940-B1 | INHIBITORS OF CRL4 UBIQUITIN LIGASE AND USES THEREOF | UNIV CORNELL (US) | 2019-06-05 | — | — | EP | claimed |
| US-20150196546-A1 | INHIBITORS OF CRL4 UBIQUITIN LIGASE AND USES THEREOF | CORNELL UNIVERSITY | 2015-07-16 | — | — | US | claimed |
| EP-2887940-A2 | INHIBITORS OF CRL4 UBIQUITIN LIGASE AND USES THEREOF | Cornell University (US) | 2015-07-01 | — | — | EP | claimed |
| WO-2014031759-A2 | INHIBITORS OF CRL4 UBIQUITIN LIGASE AND USES THEREOF | CORNELL UNIVERSITY (US) | 2014-02-27 | — | — | WO | claimed |
| US-10617683-B2 | Inhibitors of CRL4 ubiquitin ligase and uses thereof | CORNELL UNIVERSITY (US) | 2020-04-14 | — | — | US | disclosed |
| EP-2887940-B1 | INHIBITORS OF CRL4 UBIQUITIN LIGASE AND USES THEREOF | UNIV CORNELL (US) | 2019-06-05 | — | — | EP | disclosed |
| US-20150196546-A1 | INHIBITORS OF CRL4 UBIQUITIN LIGASE AND USES THEREOF | CORNELL UNIVERSITY | 2015-07-16 | — | — | US | disclosed |