Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CUL4A | Q13619 | 5/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | ALPI | P09923 | 2/20 | 0.41 |
| ▸ | ALPG | P10696 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 6/20 | 0.38 |
| ▸ | MAOB | P27338 | 6/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 4/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21043638 | 0.86 | CUL4A (0.53) | CUL4AGAAALPIALPGKDM4E | |
| SCHEMBL21043634 | 0.84 | CUL4A (0.51) | CUL4AGAAALPIALPGKDM4E | |
| SCHEMBL21043632 | 0.75 | CUL4A (0.55) | CUL4AGAAALPIALPGKDM4E | |
| SCHEMBL21043640 | 0.73 | CUL4A (0.53) | CUL4AGAAALPIALPGKDM4E | |
| SCHEMBL21043637 | 0.73 | CUL4A (0.52) | CUL4AMAOAMAOB | |
| SCHEMBL17434665 | 0.68 | NPC1 (0.32) | GAAMAPTHPGDLMNAPKM | |
| SCHEMBL9234344 | 0.65 | L3MBTL1 (0.34) | MAPTHPGDALDH1A1HSD17B10TDP1 | |
| SCHEMBL6695069 | 0.64 | ALDH1A1 (0.47) | KDM4EMAPTHPGDHTTKMT2A | |
| SCHEMBL7096241 | 0.63 | ESR2 (0.46) | HPGD | |
| SCHEMBL27449727 | 0.62 | TAAR1 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2887940-B1 | INHIBITORS OF CRL4 UBIQUITIN LIGASE AND USES THEREOF | UNIV CORNELL (US) | 2019-06-05 | — | — | EP | claimed |