Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | DDR2 | Q16832 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | NAMPT | P43490 | 3/20 | 0.43 |
| ▸ | IDH2 | P48735 | 3/20 | 0.42 |
| ▸ | RAF1 | P04049 | 3/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.41 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.40 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16990636 | 0.91 | ALDH1A1 (0.50) | ALDH1A1DDR2LMNANAMPTIDH2 | |
| SCHEMBL15574724 | 0.90 | DDR2 (0.59) | ALDH1A1DDR2LMNARAF1 | |
| SCHEMBL15575245 | 0.85 | MEN1 (0.47) | ALDH1A1DDR2LMNANAMPTRAF1 | |
| SCHEMBL15574734 | 0.83 | CYP1A2 (0.52) | DDR2LMNANAMPTIDH2RAF1 | |
| SCHEMBL16990650 | 0.81 | DDR2 (0.47) | ALDH1A1DDR2LMNANAMPTRAF1 | |
| SCHEMBL16990630 | 0.81 | DDR2 (0.52) | ALDH1A1DDR2LMNANAMPTIDH2 | |
| SCHEMBL16990582 | 0.80 | RAF1 (0.51) | ALDH1A1DDR2LMNANAMPTRAF1 | |
| SCHEMBL15574587 | 0.80 | DDR2 (0.63) | ALDH1A1DDR2RAF1 | |
| SCHEMBL16990595 | 0.80 | DDR2 (0.59) | ALDH1A1DDR2NAMPTRAF1TRPV1 | |
| SCHEMBL2334638 | 0.79 | ALDH1A1 (0.63) | ALDH1A1IDH2RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2890380-A2 | DDR2 INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS | Merck Patent GmbH (DE) | 2015-07-08 | — | — | EP | disclosed |
| WO-2014032755-A2 | DDR2 INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS | MERCK PATENT GMBH (DE) | 2014-03-06 | — | — | WO | disclosed |