Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | DDR2 | Q16832 | 4/20 | 0.47 |
| ▸ | NAMPT | P43490 | 3/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.46 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.44 |
| ▸ | PRMT6 | Q96LA8 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15574734 | 0.89 | CYP1A2 (0.52) | MEN1KMT2ADDR2NAMPTTRPV1 | |
| SCHEMBL16990740 | 0.88 | DDR2 (0.55) | MEN1KMT2ADDR2LMNASMN1; SMN2 | |
| SCHEMBL16990650 | 0.87 | DDR2 (0.47) | DDR2NAMPTTRPV1CARM1PRMT6 | |
| SCHEMBL15573083 | 0.86 | DDR2 (0.66) | MEN1KMT2ADDR2MAPK14RAF1 | |
| SCHEMBL16990582 | 0.86 | RAF1 (0.51) | KMT2ADDR2NAMPTTRPV1CARM1 | |
| SCHEMBL16990595 | 0.85 | DDR2 (0.59) | KMT2ADDR2NAMPTTRPV1CARM1 | |
| SCHEMBL15575327 | 0.85 | ALDH1A1 (0.54) | DDR2NAMPTTRPV1CARM1PRMT6 | |
| SCHEMBL15573112 | 0.81 | L3MBTL1 (0.52) | KMT2ADDR2NAMPTLMNASMN1; SMN2 | |
| SCHEMBL15574745 | 0.81 | RAF1 (0.59) | KMT2ADDR2NAMPTTRPV1LMNA | |
| SCHEMBL15575289 | 0.79 | DDR2 (0.65) | KMT2ADDR2NAMPTLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2890380-A2 | DDR2 INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS | Merck Patent GmbH (DE) | 2015-07-08 | — | — | EP | disclosed |
| WO-2014032755-A2 | DDR2 INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS | MERCK PATENT GMBH (DE) | 2014-03-06 | — | — | WO | disclosed |