Mepenzolate

Mepenzolate

SCHEMBL15575855

C[N+]1(C)CCCC(OC(=O)C(O)(c2ccccc2)c2ccccc2)C1.C[N+]1(C)CCCC(OC(=O)C(O)(c2ccccc2)c2ccccc2)C1.C[N+]1(C)CCCC(OC(=O)C(O)(c2ccccc2)c2ccccc2)C1.C[N+]1(C)CCCC(OC(=O)C(O)(c2ccccc2)c2ccccc2)C1.[Br-].[Br-].[Br-].[Br-]

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

CHRM1CHRM3

The experimentally established mechanism targets of Mepenzolate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CHRM3 known ✓ P20309 12/20 1.00
CHRM1 known ✓ P11229 4/20 0.76
CHRM2 P08172 11/20 1.00
SLC22A1 O15245 1/20 1.00
KCNH2 Q12809 5/20 0.97
CYP2D6 P10635 3/20 0.97
LMNA P02545 2/20 0.97
SLC6A4 P31645 2/20 0.97
CYP2C19 P33261 1/20 0.97
RAB9A P51151 1/20 0.78
HRH1 P35367 3/20 0.76
CHRM4 P08173 2/20 0.65
CHRM5 P08912 2/20 0.65
HTR2B P41595 1/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Mepenzolate SCHEMBL147471 1.00 CHRM3 (1.00) CHRM3CHRM2SLC22A1KCNH2CYP2D6
Mepenzolate SCHEMBL15575981 1.00 CHRM3 (1.00) CHRM3CHRM2SLC22A1KCNH2CYP2D6
Mepenzolate SCHEMBL99030 1.00 CHRM3 (1.00) CHRM3CHRM2SLC22A1KCNH2CYP2D6
Mepenzolate SCHEMBL17008166 1.00 CHRM3 (1.00) CHRM3CHRM2SLC22A1KCNH2CYP2D6
Mepenzolate SCHEMBL15865414 0.99 CHRM3 (0.97) CHRM3CHRM2SLC22A1KCNH2CYP2D6
Mepenzolate SCHEMBL9441937 0.99 CHRM3 (0.97) CHRM3CHRM2SLC22A1KCNH2CYP2D6
Mepenzolate SCHEMBL3401786 0.99 CHRM3 (0.97) CHRM3CHRM2SLC22A1KCNH2CYP2D6
Mepenzolate SCHEMBL19411950 0.99 CHRM3 (0.97) CHRM3CHRM2SLC22A1KCNH2CYP2D6
Mepenzolate SCHEMBL2994933 0.99 CHRM3 (1.00) CHRM3CHRM2SLC22A1KCNH2CYP2D6
Mepenzolate SCHEMBL17071946 0.99 CHRM3 (1.00) CHRM3CHRM2SLC22A1KCNH2CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170198027-A1 PROCESS OF AFOD AND AFCC AND MANUFACTURING AND PURIFICATION PROCESSES OF PROTEINS HOANG KIEU (US) 2017-07-13 US disclosed
WO-2013116482-A9 PROCESS OF AFOD AND AFCC AND MANUFACTURING AND PURIFICATION PROCESSES OF PROTEINS SHANGHAI RAAS BLOOD PRODUCTS CO., LTD. (CN) 2014-03-06 WO disclosed