Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Mepenzolate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 known ✓ | P20309 | 12/20 | 1.00 |
| ▸ | CHRM1 known ✓ | P11229 | 4/20 | 0.76 |
| ▸ | CHRM2 | P08172 | 11/20 | 1.00 |
| ▸ | SLC22A1 | O15245 | 1/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.97 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.97 |
| ▸ | LMNA | P02545 | 2/20 | 0.97 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.97 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.97 |
| ▸ | RAB9A | P51151 | 1/20 | 0.78 |
| ▸ | HRH1 | P35367 | 3/20 | 0.76 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.65 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.65 |
| ▸ | HTR2B | P41595 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mepenzolate SCHEMBL147471 | 1.00 | CHRM3 (1.00) | CHRM3CHRM2SLC22A1KCNH2CYP2D6 | |
| Mepenzolate SCHEMBL15575981 | 1.00 | CHRM3 (1.00) | CHRM3CHRM2SLC22A1KCNH2CYP2D6 | |
| Mepenzolate SCHEMBL15575855 | 1.00 | CHRM3 (1.00) | CHRM3CHRM2SLC22A1KCNH2CYP2D6 | |
| Mepenzolate SCHEMBL99030 | 1.00 | CHRM3 (1.00) | CHRM3CHRM2SLC22A1KCNH2CYP2D6 | |
| Mepenzolate SCHEMBL15865414 | 0.99 | CHRM3 (0.97) | CHRM3CHRM2SLC22A1KCNH2CYP2D6 | |
| Mepenzolate SCHEMBL9441937 | 0.99 | CHRM3 (0.97) | CHRM3CHRM2SLC22A1KCNH2CYP2D6 | |
| Mepenzolate SCHEMBL3401786 | 0.99 | CHRM3 (0.97) | CHRM3CHRM2SLC22A1KCNH2CYP2D6 | |
| Mepenzolate SCHEMBL19411950 | 0.99 | CHRM3 (0.97) | CHRM3CHRM2SLC22A1KCNH2CYP2D6 | |
| Mepenzolate SCHEMBL2994933 | 0.99 | CHRM3 (1.00) | CHRM3CHRM2SLC22A1KCNH2CYP2D6 | |
| Mepenzolate SCHEMBL17071946 | 0.99 | CHRM3 (1.00) | CHRM3CHRM2SLC22A1KCNH2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3109232-A1 | OPTICALLY ACTIVE FORM OF MEPENZOLATE, AND AMELIORATING AGENT FOR CHRONIC OBSTRUCTIVE PULMONARY DISEASE WHICH CONTAINS SAME AS ACTIVE INGREDIENT | LTT Bio-Pharma Co., Ltd. (JP) | 2016-12-28 | — | — | EP | claimed |
| US-20160368873-A1 | Optically Active Form of Mepenzolate, and Ameliorating Agent for Chronic Obstructive Pulmonary Disease Which Contains Same as Active Ingredient | LTT BIO-PHARMA CO., LTD. | 2016-12-22 | — | — | US | claimed |
| EP-3109232-A1 | OPTICALLY ACTIVE FORM OF MEPENZOLATE, AND AMELIORATING AGENT FOR CHRONIC OBSTRUCTIVE PULMONARY DISEASE WHICH CONTAINS SAME AS ACTIVE INGREDIENT | LTT Bio-Pharma Co., Ltd. (JP) | 2016-12-28 | — | — | EP | disclosed |
| EP-3109232-A1 | OPTICALLY ACTIVE FORM OF MEPENZOLATE, AND AMELIORATING AGENT FOR CHRONIC OBSTRUCTIVE PULMONARY DISEASE WHICH CONTAINS SAME AS ACTIVE INGREDIENT | LTT Bio-Pharma Co., Ltd. (JP) | 2016-12-28 | — | — | EP | disclosed |
| US-20160368873-A1 | Optically Active Form of Mepenzolate, and Ameliorating Agent for Chronic Obstructive Pulmonary Disease Which Contains Same as Active Ingredient | LTT BIO-PHARMA CO., LTD. | 2016-12-22 | — | — | US | disclosed |
| US-20160368873-A1 | Optically Active Form of Mepenzolate, and Ameliorating Agent for Chronic Obstructive Pulmonary Disease Which Contains Same as Active Ingredient | LTT BIO-PHARMA CO., LTD. | 2016-12-22 | — | — | US | disclosed |
| CN-105980358-A | Methylpiperazinoate optically active form and chronic obstructive pulmonary disease ameliorating agent containing the same as active ingredient | 日本株式会社LTT生物医药 | 2016-09-28 | — | — | CN | disclosed |
| WO-2015122031-A1 | OPTICALLY ACTIVE FORM OF MEPENZOLATE, AND AMELIORATING AGENT FOR CHRONIC OBSTRUCTIVE PULMONARY DISEASE WHICH CONTAINS SAME AS ACTIVE INGREDIENT | 株式会社ＬＴＴバイオファーマ | 2015-08-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160368873-A1 | Optically Active Form of Mepenzolate, and Ameliorating Agent for Chronic Obstructive Pulmonary Disease Which Contains Same as Active Ingredient | CHRM3, CHRM1, MEP1B | CHRM3 1/4885CHRM1 2/4885CHRM2 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.