Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16293142 | 0.83 | TSHR (0.54) | TSHRHSD11B1EPHX2LMNAKMT2A | |
| SCHEMBL29017424 | 0.82 | DPP4 (0.46) | TSHRLMNAMEN1KMT2AL3MBTL1 | |
| SCHEMBL29017348 | 0.82 | DPP4 (0.46) | TSHRLMNAMEN1KMT2AL3MBTL1 | |
| SCHEMBL625584 | 0.81 | HSD11B1 (0.64) | TSHRHSD11B1EPHX2LMNAMEN1 | |
| SCHEMBL977926 | 0.81 | HSD11B1 (0.69) | TSHRHSD11B1EPHX2LMNAMEN1 | |
| SCHEMBL15577224 | 0.80 | TSHR (0.63) | TSHRHSD11B1LMNAL3MBTL1NPSR1 | |
| SCHEMBL5365797 | 0.80 | HSD11B1 (0.72) | TSHRHSD11B1EPHX2LMNAMEN1 | |
| SCHEMBL15577253 | 0.79 | DPP4 (0.43) | EPHX2LMNAMEN1KMT2AL3MBTL1 | |
| Hydrochloric Acid SCHEMBL11526870 | 0.78 | HSD11B1 (0.70) | TSHRHSD11B1EPHX2LMNAMEN1 | |
| SCHEMBL1361875 | 0.77 | TSHR (0.58) | TSHRHSD11B1EPHX2LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014041349-A1 | TETRAHYDROPYRAN-4-YLETHYLAMINO- OR TETRAHYDROPYRANYL-4-ETHYLOXY-PYRIMIDINES OR -PYRIDAZINES AS ISOPRENYLCYSTEINCARBOXYMETHYL TRANSFERASE INHIBITORS | CANCER THERAPEUTICS CRC PTY LTD (AU) | 2014-03-20 | — | — | WO | disclosed |