Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRACR2A | Q9BSW2 | 6/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | STIM1 | Q13586 | 2/20 | 0.36 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.36 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.36 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.36 |
| ▸ | CPT2 | P23786 | 1/20 | 0.35 |
| ▸ | CPT1A | P50416 | 1/20 | 0.35 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 1/20 | 0.35 |
| ▸ | HTR1B | P28222 | 1/20 | 0.35 |
| ▸ | HTR1F | P30939 | 1/20 | 0.35 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15579179 | 0.96 | CRACR2A (0.42) | CRACR2ASTIM1ORAI1TRPC1TRPC3 | |
| SCHEMBL15577342 | 0.92 | CPT2 (0.40) | CPT2CPT1ACPT1B | |
| SCHEMBL15577407 | 0.83 | STIM1 (0.43) | CRACR2ASTIM1ORAI1TRPC1TRPC3 | |
| SCHEMBL15606063 | 0.81 | CRACR2A (0.41) | CRACR2AHTTSTIM1ORAI1TRPC1 | |
| SCHEMBL15577332 | 0.81 | STIM1 (0.44) | CRACR2ASTIM1ORAI1TRPC1TRPC3 | |
| SCHEMBL15577347 | 0.80 | CRHR1 (0.49) | CRACR2ASTIM1ORAI1TRPC1TRPC3 | |
| SCHEMBL15577328 | 0.79 | STIM1 (0.46) | CRACR2AHTTSTIM1ORAI1TRPC1 | |
| SCHEMBL15577374 | 0.79 | STIM1 (0.46) | CRACR2AHTTSTIM1ORAI1TRPC1 | |
| SCHEMBL15577410 | 0.78 | STIM1 (0.42) | CRACR2ASTIM1ORAI1TRPC1TRPC3 | |
| SCHEMBL15577503 | 0.78 | STIM1 (0.41) | CRACR2ASTIM1ORAI1TRPC1TRPC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2895476-A1 | 2-OXO-2,3-DIHYDRO-INDOLES FOR THE TREATMENT OF CNS DISORDERS | F. Hoffmann-La Roche AG (CH) | 2015-07-22 | — | — | EP | claimed |
| WO-2014040969-A1 | 2-OXO-2,3-DIHYDRO-INDOLES FOR THE TREATMENT OF CNS DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2014-03-20 | — | — | WO | claimed |
| EP-2895476-A1 | 2-OXO-2,3-DIHYDRO-INDOLES FOR THE TREATMENT OF CNS DISORDERS | F. Hoffmann-La Roche AG (CH) | 2015-07-22 | — | — | EP | disclosed |
| WO-2014040969-A1 | 2-OXO-2,3-DIHYDRO-INDOLES FOR THE TREATMENT OF CNS DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2014-03-20 | — | — | WO | disclosed |