Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17057374 | 0.83 | HSD17B10 (0.37) | HSD17B10CYP3A4HPGDCRHBPCRHR2 | |
| SCHEMBL17512483 | 0.82 | THRB (0.35) | CYP3A4MAPTALDH1A1CA2 | |
| SCHEMBL27321635 | 0.79 | HSD17B10 (0.37) | HSD17B10CYP3A4HPGDCRHBPCRHR2 | |
| SCHEMBL21598708 | 0.78 | PLAU (0.43) | CYP3A4HPGDMAPTKDM4EALDH1A1 | |
| SCHEMBL1432782 | 0.76 | ALDH1A1 (0.38) | HPGDMAPTALDH1A1L3MBTL1 | |
| SCHEMBL16586047 | 0.74 | TDP1 (0.55) | CYP3A4MAPTALDH1A1GAATDP1 | |
| SCHEMBL30636549 | 0.74 | TDP1 (0.55) | CYP3A4MAPTALDH1A1GAATDP1 | |
| SCHEMBL364169 | 0.73 | HSD17B10 (0.37) | HSD17B10CYP3A4HPGDCRHBPCRHR2 | |
| SCHEMBL1433091 | 0.71 | TDP1 (0.30) | MAPTTDP1L3MBTL1 | |
| SCHEMBL21049713 | 0.71 | KMT2A (0.34) | MAPTTDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2895488-A1 | TRICYCLIC GYRASE INHIBITORS FOR USE AS ANTIBACTERIAL AGENTS | Trius Therapeutics, Inc. (US) | 2015-07-22 | — | — | EP | disclosed |
| WO-2014043272-A1 | TRICYCLIC GYRASE INHIBITORS FOR USE AS ANTIBACTERIAL AGENTS | TRIUS THERAPEUTICS INC. (US) | 2014-03-20 | — | — | WO | disclosed |