Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FCER2 | P06734 | 4/20 | 0.53 |
| ▸ | ELANE | P08246 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | PPARG | P37231 | 2/20 | 0.47 |
| ▸ | PPARA | Q07869 | 2/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.46 |
| ▸ | PPARD | Q03181 | 1/20 | 0.46 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.45 |
| ▸ | CTSL | P07711 | 1/20 | 0.45 |
| ▸ | CTSB | P07858 | 1/20 | 0.45 |
| ▸ | MC5R | P33032 | 2/20 | 0.45 |
| ▸ | MC1R | Q01726 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2779293 | 0.88 | PPARG (0.53) | KDM4ELMNAGAAHTTSMN1; SMN2 | |
| SCHEMBL2779289 | 0.88 | PPARG (0.53) | KDM4ELMNAGAAHTTSMN1; SMN2 | |
| SCHEMBL30436738 | 0.83 | ATM (0.51) | LMNAGAAPPARGPPARAPPARD | |
| SCHEMBL2722699 | 0.83 | ELANE (0.53) | FCER2ELANEPPARGEPHX1CYP1A2 | |
| SCHEMBL1053745 | 0.83 | ELANE (0.53) | FCER2ELANEPPARGEPHX1CYP1A2 | |
| SCHEMBL28085739 | 0.82 | MAPT (0.52) | FCER2ELANEKDM4EGAAEPHX1 | |
| SCHEMBL16599266 | 0.80 | SYK (0.49) | ELANEKDM4EGAAHTTSMN1; SMN2 | |
| SCHEMBL28085748 | 0.79 | MAPK1 (0.49) | FCER2ELANEGAASMN1; SMN2PPARG | |
| SCHEMBL4522563 | 0.79 | FPR2 (0.58) | FCER2ELANESMN1; SMN2PPARGEPHX1 | |
| SCHEMBL27723701 | 0.79 | FPR2 (0.58) | FCER2ELANESMN1; SMN2PPARGEPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2895482-A1 | HIV PROTEASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2015-07-22 | — | — | EP | claimed |
| WO-2014043019-A1 | HIV PROTEASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2014-03-20 | — | — | WO | claimed |