Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 19/20 | 0.74 |
| ▸ | THRA | P10827 | 17/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15578029 | 0.85 | THRB (0.80) | THRBTHRA | |
| SCHEMBL22668174 | 0.83 | THRB (0.77) | THRBTHRA | |
| SCHEMBL22660347 | 0.82 | THRB (0.74) | THRBTHRA | |
| SCHEMBL21749520 | 0.81 | THRB (1.00) | THRBTHRA | |
| SCHEMBL15578325 | 0.81 | KMT2A (0.49) | THRBTHRA | |
| SCHEMBL2927022 | 0.80 | THRB (1.00) | THRBTHRA | |
| SCHEMBL22668180 | 0.80 | THRB (0.71) | THRBTHRA | |
| SCHEMBL24032552 | 0.79 | THRB (0.70) | THRBTHRA | |
| SCHEMBL22660390 | 0.79 | THRB (0.70) | THRBTHRA | |
| SCHEMBL28924887 | 0.79 | THRB (0.62) | THRBTHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4691557-A2 | METHOD OF SYNTHESIZING THYROID HORMONE ANALOGS AND POLYMORPHS THEREOF | Madrigal Pharmaceuticals, Inc. (US) | 2026-02-11 | — | — | EP | disclosed |
| EP-4406594-A2 | METHOD OF SYNTHESIZING THYROID HORMONE ANALOGS AND POLYMORPHS THEREOF | Madrigal Pharmaceuticals, Inc. (US) | 2024-07-31 | — | — | EP | disclosed |
| US-11986481-B2 | Method of synthesizing thyroid hormone analogs and polymorphs thereof | MADRIGAL PHARMACEUTICALS, INC. (US) | 2024-05-21 | — | — | US | disclosed |
| US-20240148742-A1 | METHOD OF SYNTHESIZING THYROID HORMONE ANALOGS AND POLYMORPHS THEREOF | MADRIGAL PHARMACEUTICALS, INC. | 2024-05-09 | — | — | US | disclosed |
| EP-4023641-B1 | METHOD OF SYNTHESIZING THYROID HORMONE ANALOGS AND POLYMORPHS THEREOF | MADRIGAL PHARMACEUTICALS INC (US) | 2024-05-01 | — | — | EP | disclosed |
| US-20240122936-A1 | METHOD OF SYNTHESIZING THYROID HORMONE ANALOGS AND POLYMORPHS THEREOF | LSI FINANCING LLC, AS ADMINISTRATIVE AGENT | 2024-04-18 | — | — | US | disclosed |
| US-20230210856-A1 | METHODS OF SYNTHESIZING THYROID HORMONE ANALOGS AND POLYMORPHS THEREOF | MADRIGAL PHARMACEUTICALS, INC. | 2023-07-06 | — | — | US | disclosed |
| US-20230210856-A1 | METHODS OF SYNTHESIZING THYROID HORMONE ANALOGS AND POLYMORPHS THEREOF | MADRIGAL PHARMACEUTICALS, INC. | 2023-07-06 | — | — | US | disclosed |
| US-11564926-B2 | Methods of synthesizing thyroid hormone analogs and polymorphs thereof | MADRIGAL PHARMACEUTICALS, INC. (US) | 2023-01-31 | — | — | US | disclosed |
| EP-4023641-A2 | METHOD OF SYNTHESIZING THYROID HORMONE ANALOGS AND POLYMORPHS THEREOF | Madrigal Pharmaceuticals, Inc. (US) | 2022-07-06 | — | — | EP | disclosed |
| US-20160243126-A1 | METHOD OF SYNTHESIZING THYROID HORMONE ANALOGS AND POLYMORPHS THEREOF | LSI FINANCING LLC, AS ADMINISTRATIVE AGENT | 2016-08-25 | — | — | US | disclosed |
| US-9266861-B2 | Method of synthesizing thyroid hormone analogs and polymorphs thereof | MADRIGAL PHARMACEUTICALS, INC. (US) | 2016-02-23 | — | — | US | disclosed |
| US-9266861-B2 | Method of synthesizing thyroid hormone analogs and polymorphs thereof | MADRIGAL PHARMACEUTICALS, INC. (US) | 2016-02-23 | — | — | US | disclosed |
| US-9266861-B2 | Method of synthesizing thyroid hormone analogs and polymorphs thereof | MADRIGAL PHARMACEUTICALS, INC. (US) | 2016-02-23 | — | — | US | disclosed |
| US-20150203473-A1 | METHOD OF SYNTHESIZING THYROID HORMONE ANALOGS AND POLYMORPHS THEREOF | LSI FINANCING LLC, AS ADMINISTRATIVE AGENT | 2015-07-23 | — | — | US | disclosed |
| US-20150203473-A1 | METHOD OF SYNTHESIZING THYROID HORMONE ANALOGS AND POLYMORPHS THEREOF | LSI FINANCING LLC, AS ADMINISTRATIVE AGENT | 2015-07-23 | — | — | US | disclosed |
| US-20150203473-A1 | METHOD OF SYNTHESIZING THYROID HORMONE ANALOGS AND POLYMORPHS THEREOF | LSI FINANCING LLC, AS ADMINISTRATIVE AGENT | 2015-07-23 | — | — | US | disclosed |
| EP-2895466-A1 | METHOD OF SYNTHESIZING THYROID HORMONE ANALOGS AND POLYMORPHS THEREOF | Madrigal Pharmaceuticals, Inc. (US) | 2015-07-22 | — | — | EP | disclosed |
| WO-2014043706-A1 | METHOD OF SYNTHESIZING THYROID HORMONE ANALOGS AND POLYMORPHS THEREOF | MADRIGAL PHARMACEUTICALS, INC. (US) | 2014-03-20 | — | — | WO | disclosed |
| WO-2014043706-A1 | METHOD OF SYNTHESIZING THYROID HORMONE ANALOGS AND POLYMORPHS THEREOF | MADRIGAL PHARMACEUTICALS, INC. (US) | 2014-03-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11564926-B2 | Methods of synthesizing thyroid hormone analogs and polymorphs thereof | THRB, TSHR, TRHR | THRB 1/4885THRA 4/4885 |
| US-11986481-B2 | Method of synthesizing thyroid hormone analogs and polymorphs thereof | THRB, TSHR, TRHR | THRB 1/4885THRA 4/4885 |
| US-20160243126-A1 | METHOD OF SYNTHESIZING THYROID HORMONE ANALOGS AND POLYMORPHS THEREOF | THRB, TSHR, TRHR | THRB 1/4885THRA 4/4885 |
| US-20230210856-A1 | METHODS OF SYNTHESIZING THYROID HORMONE ANALOGS AND POLYMORPHS THEREOF | THRB, TSHR, TRHR | THRB 1/4885THRA 4/4885 |
| US-20240122936-A1 | METHOD OF SYNTHESIZING THYROID HORMONE ANALOGS AND POLYMORPHS THEREOF | THRB, TSHR, TRHR | THRB 1/4885THRA 4/4885 |
| US-20240148742-A1 | METHOD OF SYNTHESIZING THYROID HORMONE ANALOGS AND POLYMORPHS THEREOF | THRB, TSHR, TRHR | THRB 1/4885THRA 4/4885 |
| US-20150203473-A1 | METHOD OF SYNTHESIZING THYROID HORMONE ANALOGS AND POLYMORPHS THEREOF | THRB, TSHR, TRHR | THRB 1/4885THRA 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.