Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.61 |
| ▸ | NPC1 | O15118 | 6/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.53 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.52 |
| ▸ | GCK | P35557 | 5/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | SCD | O00767 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12021592 | 0.91 | RAB9A (0.64) | RAB9ANPC1HPGDSMN1; SMN2KCNK3 | |
| SCHEMBL6919419 | 0.80 | NPC1 (0.66) | RAB9ANPC1HPGDSMN1; SMN2KCNK3 | |
| SCHEMBL6918739 | 0.80 | RAB9A (0.66) | RAB9ANPC1HPGDSMN1; SMN2KCNK3 | |
| SCHEMBL30099022 | 0.78 | RAB9A (0.77) | RAB9ANPC1HPGDSMN1; SMN2KCNK3 | |
| SCHEMBL2658269 | 0.76 | GCK (0.55) | RAB9ANPC1HPGDSMN1; SMN2KCNK3 | |
| SCHEMBL27652020 | 0.76 | RAB9A (0.74) | RAB9ANPC1HPGDSMN1; SMN2KCNK3 | |
| SCHEMBL12021365 | 0.76 | GCK (0.70) | GCK | |
| SCHEMBL2664741 | 0.76 | RAB9A (0.73) | RAB9ANPC1HPGDSMN1; SMN2KCNK3 | |
| SCHEMBL4755922 | 0.74 | RAB9A (0.71) | RAB9ANPC1HPGDSMN1; SMN2KCNK3 | |
| SCHEMBL2656743 | 0.74 | GCK (0.74) | GCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2185570-B1 | NOVEL ACTIVATORS OF GLUCOKINASE | METABASIS THERAPEUTICS INC (US) | 2014-03-19 | — | — | EP | disclosed |