Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | IDO1 | P14902 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | ELANE | P08246 | 1/20 | 0.46 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28576096 | 0.85 | KDM4E (0.50) | RXFP1IDO1LMNASMN1; SMN2CYP1A2 | |
| SCHEMBL21251514 | 0.84 | SMN1; SMN2 (0.47) | RXFP1LMNAPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL13209430 | 0.84 | RXFP1 (0.49) | RXFP1IDO1LMNAPOLBSMN1; SMN2 | |
| SCHEMBL15368377 | 0.83 | RXFP1 (0.59) | RXFP1IDO1LMNAPOLBELANE | |
| SCHEMBL222446 | 0.83 | RXFP1 (0.55) | RXFP1LMNAPOLBSMN1; SMN2KDM4E | |
| SCHEMBL29992092 | 0.83 | RXFP1 (0.59) | RXFP1IDO1LMNAPOLBELANE | |
| SCHEMBL29663621 | 0.83 | RXFP1 (0.55) | RXFP1IDO1LMNAPOLBELANE | |
| SCHEMBL29702265 | 0.83 | RXFP1 (0.55) | RXFP1LMNAPOLBSMN1; SMN2KDM4E | |
| SCHEMBL28493853 | 0.82 | KDM4E (0.60) | LMNAELANEPRTN3SMN1; SMN2CYP1A2 | |
| SCHEMBL15725383 | 0.82 | RXFP1 (0.47) | RXFP1IDO1LMNAPOLBELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2398789-B1 | SPIROPYRROLIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME (US) | 2014-03-19 | — | — | EP | disclosed |
| WO-2010094242-A1 | SPIROPYRROLIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME CORP. (US) | 2010-08-26 | — | — | WO | disclosed |
| CN-1802361-A | M-stage kinesin inhibitor | KYOWA HAKKO KOGYO KK (JP) | 2006-07-12 | — | — | CN | disclosed |