SCHEMBL222446

SCHEMBL222446

CC(C)(C)OC(=O)Nc1ccccc1C(=O)O

nearest known ligand 0.55

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
RXFP1 Q9HBX9 1/20 0.55
KMT2A Q03164 3/20 0.51
MASP2 O00187 1/20 0.51
POLB P06746 2/20 0.51
KDM4E B2RXH2 1/20 0.51
CA12 O43570 2/20 0.50
CA2 P00918 2/20 0.50
CA9 Q16790 2/20 0.50
HCAR2 Q8TDS4 2/20 0.50
LMNA P02545 1/20 0.50
MEN1 O00255 2/20 0.49
PKM P14618 1/20 0.49
DHODH Q02127 2/20 0.48
TRPM8 Q7Z2W7 1/20 0.48
ABCC1 P33527 1/20 0.48
BRD9 Q9H8M2 1/20 0.47
NPC1 O15118 1/20 0.47
RAB9A P51151 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29702265 1.00 RXFP1 (0.55) RXFP1KMT2AMASP2POLBKDM4E
SCHEMBL30173444 0.87 KMT2A (0.54) RXFP1KMT2AMASP2POLBKDM4E
SCHEMBL1690938 0.87 KMT2A (0.54) RXFP1KMT2AMASP2POLBKDM4E
SCHEMBL29992092 0.87 RXFP1 (0.59) RXFP1KMT2APOLBLMNAMEN1
SCHEMBL15368377 0.87 RXFP1 (0.59) RXFP1KMT2APOLBLMNAMEN1
SCHEMBL29663621 0.87 RXFP1 (0.55) RXFP1KMT2APOLBKDM4ELMNA
SCHEMBL5812852 0.86 KDM4E (0.51) RXFP1KMT2APOLBKDM4ELMNA
SCHEMBL3248129 0.86 NPC1 (0.54) RXFP1KMT2AKDM4ELMNAMEN1
SCHEMBL2703465 0.86 ALDH1A1 (0.54) RXFP1KMT2APOLBLMNABRD9
SCHEMBL2880191 0.86 LMNA (0.54) RXFP1KMT2APOLBCA12LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 411 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117567537-A Synthesis and use of reversible termination nucleotide based on pH sensitive connecting unit 上海交通大学 2024-02-20 CN claimed
US-20020019013-A1 Combined resin method for high-speed synthesis of combinatorial libraries ADVANCED SYNTECH, LLC 2002-02-14 US claimed
EP-4746966-A1 4-AMINO-2,6-BIS(PHENYLMETHYLENE)CYCLOHEXANONES AND THEIR USE Ustav Organicke Chemie a Biochemie AV CR, v.v.i. (CZ) 2026-05-27 EP disclosed
US-20260098058-A1 COMPOUND - DIAGNOSTIC MARKER FOR OVARIAN CANCER, METHOD FOR DETECTING ENZYMATIC ACTIVITY, METHOD FOR DIAGNOSIS OF OVARIAN CANCER, KIT COMPRISING THE COMPOUND, USES OF THE COMPOUND AND METHOD FOR THE TREATMENT OF OVARIAN CANCER URTESTE S.A. (PL) 2026-04-09 US disclosed
US-12570655-B2 Cysteine covalent modifiers of AKT1 and uses thereof TERREMOTO BIOSCIENCES, INC. (US) 2026-03-10 US disclosed
US-12564583-B2 Small molecules against cereblon to enhance effector T cell function Lee Moffitt Cancer Center and Research Institute, Inc. (US) 2026-03-03 US disclosed
US-20250376711-A1 COMPOUND-DIAGNOSTIC MARKER FOR UTERINE BODY CANCER, METHOD FOR DETECTING ENZYMATIC ACTIVITY, METHOD FOR DIAGNOSIS OF UTERINE BODY CANCER, KIT COMPRISING THE COMPOUND, USES OF THE COMPOUND AND METHOD FOR THE TREATMENT OF UTERINE BODY CANCER URTESTE S.A. (PL) 2025-12-11 US disclosed
EP-4649167-A2 COMPOUND - DIAGNOSTIC MARKER FOR BILIARY TRACT CANCER, METHOD FOR DETECTING ENZYMATIC ACTIVITY, METHOD FOR DIAGNOSIS OF BILIARY TRACT CANCER, KIT COMPRISING THE COMPOUND, USES OF THE COMPOUND AND METHOD FOR THE TREATMENT OF BILIARY TRACT CANCER Urteste S.A. (PL) 2025-11-19 EP disclosed
WO-2025216642-A1 ENZYMATIC ACTIVITY BASED METHOD AND MARKER FOR THE DIAGNOSIS OF BRAIN TUMOUR URTESTE S.A. (PL) 2025-10-16 WO disclosed
US-20250289819-A1 CYSTEINE COVALENT MODIFIERS OF AKT1 AND USES THEREOF TERREMOTO BIOSCIENCES, INC. 2025-09-18 US disclosed
US-20250270617-A1 Compound - diagnostic marker for kidney cancer, method for detecting enzymatic activity, method for diagnosis of kidney cancer, kit comprising the compound, uses of the compound and method for the treatment of kidney cancer URTESTE S.A. (PL) 2025-08-28 US disclosed
WO-1996033209-A1 PEPTIDYL DERIVATIVES AS INHIBITORS OF PRO-APOPTOTIC CYSTEINE PROTEINASES MERCK FROSST CANADA INC. (CA) 1996-10-24 WO disclosed
WO-1996033268-A1 APOPAIN MERCK & CO., INC. (US) 1996-10-24 WO disclosed
EP-0528854-B1 FLUOROGENIC PEPTIDES AND THEIR USE IN THE DETERMINATION OF ENZYMATIC ACTIVITIES CARLSBERG AS (DK) 1994-12-28 EP disclosed
EP-0625978-A1 PIPERAZINE AND PIPERIDINE DERIVATIVES, AND THEIR USE AS ANTIPSYCHOTICS THE WELLCOME FOUNDATION LIMITED (GB) 1994-11-30 EP disclosed
US-5298409-A Of esters, antigen diastereomers which are stable analogs of the unstable ester transition states THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1994-03-29 US disclosed
WO-1993016073-A1 PIPERAZINE AND PIPERIDINE DERIVATIVES, AND THEIR USE AS ANTIPSYCHOTICS THE WELLCOME FOUNDATION LIMITED (GB) 1993-08-19 WO disclosed
EP-0528854-A1 FLUOROGENIC PEPTIDES AND THEIR USE IN THE DETERMINATION OF ENZYMATIC ACTIVITIES. CARLSBERG AS (DK) 1993-03-03 EP disclosed
US-5190865-A Antibody-enhanced stereospecific hydrolyses THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1993-03-02 US disclosed
WO-1991016336-A1 FLUOROGENIC PEPTIDES AND THEIR USE IN THE DETERMINATION OF ENZYMATIC ACTIVITIES CARLSBERG A/S (DK) 1991-10-31 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020019013-A1 Combined resin method for high-speed synthesis of combinatorial libraries CPSF1, CPSF6, PLAU RXFP1 2819/4885KMT2A 1951/4885MASP2 246/4885
US-12570655-B2 Cysteine covalent modifiers of AKT1 and uses thereof AKT1, AKT2, AKT3 RXFP1 2737/4885KMT2A 1229/4885MASP2 4799/4885
US-12564583-B2 Small molecules against cereblon to enhance effector T cell function CRBN, CD4, ICOS RXFP1 2676/4885KMT2A 3331/4885MASP2 2132/4885
US-20250289819-A1 CYSTEINE COVALENT MODIFIERS OF AKT1 AND USES THEREOF AKT1, AKT2, AKT3 RXFP1 4124/4885KMT2A 932/4885MASP2 4167/4885
US-20260098058-A1 COMPOUND - DIAGNOSTIC MARKER FOR OVARIAN CANCER, METHOD FOR DETECTING ENZYMATIC ACTIVITY, METHOD FOR DIAGNOSIS OF OVARIAN CANCER, KIT COMPRISING THE COMPOUND, USES OF THE COMPOUND AND METHOD FOR THE TREATMENT OF OVARIAN CANCER DNPEP, ANPEP, CA9 RXFP1 2731/4885KMT2A 3068/4885MASP2 201/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.