Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 14/20 | 0.47 |
| ▸ | PDE4A | P27815 | 12/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 12/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 12/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15580951 | 0.94 | PDE4B (0.51) | PDE4BPDE4APDE4CPDE4DALDH1A1 | |
| SCHEMBL16572255 | 0.90 | PDE4B (0.50) | PDE4BPDE4APDE4CPDE4DALDH1A1 | |
| SCHEMBL15580957 | 0.89 | PDE4B (0.47) | PDE4BPDE4APDE4CPDE4DALDH1A1 | |
| SCHEMBL12934644 | 0.84 | PDE4B (0.39) | PDE4BPDE4APDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL15580934 | 0.84 | PDE4B (0.49) | PDE4BPDE4APDE4CPDE4DALDH1A1 | |
| SCHEMBL16229259 | 0.84 | PDE4B (0.39) | PDE4BPDE4APDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL15580926 | 0.83 | PDE4B (0.59) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL15580915 | 0.83 | PDE4B (0.59) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL15869362 | 0.83 | PDE4B (0.59) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL15869339 | 0.83 | PDE4B (0.59) | PDE4BPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9434689-B2 | Processes for the preparation of isoindole compounds and isotopologues thereof | CELGENE CORPORATION (US) | 2016-09-06 | — | — | US | disclosed |
| US-20150183739-A1 | PROCESSES FOR THE PREPARATION OF ISOINDOLE COMPOUNDS AND ISOTOPOLOGUES THEREOF | AMGEN INC. | 2015-07-02 | — | — | US | disclosed |
| US-8981117-B2 | Processes for the preparation of isoindole compounds and isotopologues thereof | CELGENE CORPORATION (US) | 2015-03-17 | — | — | US | disclosed |
| US-20140081032-A1 | PROCESSES FOR THE PREPARATION OF ISOINDOLE COMPOUNDS AND ISOTOPOLOGUES THEREOF | CELGENE CORPORATION (US) | 2014-03-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150183739-A1 | PROCESSES FOR THE PREPARATION OF ISOINDOLE COMPOUNDS AND ISOTOPOLOGUES THEREOF | HPD, DHPS, IDH2 | PDE4B 1021/4885PDE4A 1248/4885PDE4C 1388/4885 |
| US-20140081032-A1 | PROCESSES FOR THE PREPARATION OF ISOINDOLE COMPOUNDS AND ISOTOPOLOGUES THEREOF | HPD, DHPS, IDH2 | PDE4B 1021/4885PDE4A 1248/4885PDE4C 1388/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.