Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 4/20 | 0.39 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.39 |
| ▸ | MAP2K4 | P45985 | 3/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | WNT1 | P04628 | 2/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.34 |
| ▸ | PTGES | O14684 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2398355 | 0.83 | PDPK1 (0.40) | PIM1PIM3PIM2CLK4LRRK2 | |
| SCHEMBL2396913 | 0.74 | RIPK2 (0.39) | PIM1MAP2K4BCHEACHECLK4 | |
| SCHEMBL1559214 | 0.74 | MAPK10 (0.46) | CLK4MAP4K4LRRK2KDM4EMEN1 | |
| SCHEMBL2396142 | 0.73 | PIM1 (0.38) | PIM1MAP2K4CLK4MAP4K4MAP3K5 | |
| SCHEMBL1559198 | 0.73 | PDPK1 (0.46) | MAP2K4CLK4MAP4K4LRRK2KDM4E | |
| SCHEMBL1558709 | 0.73 | NPBWR1 (0.46) | ACHEMAP4K4MEN1ALDH1A1LMNA | |
| SCHEMBL1559133 | 0.70 | MAP3K5 (0.40) | PIM1MAP4K4MAP3K5LRRK2KDM4E | |
| SCHEMBL1559354 | 0.70 | PIM1 (0.58) | PIM1PIM3PIM2MAP2K4CLK4 | |
| SCHEMBL2395253 | 0.70 | DYRK1A (0.46) | PIM1WNT1LRRK2CLK2CLK3 | |
| SCHEMBL1558243 | 0.70 | MTOR (0.36) | PIM1PIM3PIM2CLK4LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2303890-A2 | PHOSPHATIDYLINOSITOL 3 KINASE INHIBITORS | Progenics Pharmaceuticals, Inc. (US) | 2011-04-06 | — | — | EP | disclosed |
| WO-2009155527-A9 | PHOSPHATIDYLINOSITOL 3 KINASE INHIBITORS | PROGENICS PHARMACEUTICALS, INC. (US) | 2010-05-06 | — | — | WO | disclosed |
| WO-2009155527-A2 | PHOSPHATIDYLINOSITOL 3 KINASE INHIBITORS | PROGENICS PHARMACEUTICALS, INC. (US) | 2009-12-23 | — | — | WO | disclosed |