Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 7/20 | 0.38 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 6/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.36 |
| ▸ | CDK9 | P50750 | 2/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1558633 | 0.81 | MTOR (0.38) | PIM1CLK4ALDH1A1LRRK2CHEK1 | |
| SCHEMBL2398692 | 0.76 | CNR2 (0.48) | PIM1MAPK1LRRK2KDR | |
| SCHEMBL1559214 | 0.75 | MAPK10 (0.46) | CLK4MAP4K4KDM4EMEN1USP2 | |
| SCHEMBL1558709 | 0.74 | NPBWR1 (0.46) | MAP4K4MEN1ALDH1A1LMNACYP1A2 | |
| SCHEMBL2398645 | 0.74 | LRRK2 (0.42) | CLK4USP2ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL2396913 | 0.74 | RIPK2 (0.39) | PIM1CLK4MAP4K4LRRK2MAP2K4 | |
| SCHEMBL1558643 | 0.73 | PIM1 (0.39) | PIM1MAP3K5CLK4MAP4K4KDM4E | |
| SCHEMBL1559198 | 0.72 | PDPK1 (0.46) | CLK4MAP4K4KDM4EALDH1A1LMNA | |
| SCHEMBL1559133 | 0.72 | MAP3K5 (0.40) | PIM1MAP3K5MAP4K4KDM4EMEN1 | |
| SCHEMBL1559354 | 0.71 | PIM1 (0.58) | PIM1CLK4MAP4K4CDK9LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110212053-A1 | PHOSPHATIDYLINOSITOL 3 KINASE INHIBITORS | PROGENICS PHARMACEUTICALS, INC. | 2011-09-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110212053-A1 | PHOSPHATIDYLINOSITOL 3 KINASE INHIBITORS | PIK3CA, AKT1, PIK3R5 | PIM1 417/4885MAP3K5 56/4885CLK4 814/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.