Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY14 | Q15391 | 1/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 9/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 9/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 9/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 8/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 8/20 | 0.41 |
| ▸ | BPTF | Q12830 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | CHRNB3 | Q05901 | 3/20 | 0.35 |
| ▸ | CHRNA6 | Q15825 | 3/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16941423 | 1.00 | P2RY14 (0.42) | P2RY14CHRNA7CHRNB2CHRNA4CHRNB4 | |
| SCHEMBL14704704 | 1.00 | P2RY14 (0.42) | P2RY14CHRNA7CHRNB2CHRNA4CHRNB4 | |
| SCHEMBL15596503 | 1.00 | P2RY14 (0.42) | P2RY14CHRNA7CHRNB2CHRNA4CHRNB4 | |
| SCHEMBL22010508 | 0.86 | CHRNB2 (0.45) | P2RY14CHRNA7CHRNB2CHRNA4CHRNB4 | |
| SCHEMBL5938794 | 0.82 | CHRNA7 (0.52) | P2RY14CHRNA7CHRNB2CHRNA4CHRNB4 | |
| SCHEMBL5938773 | 0.82 | CHRNA7 (0.52) | P2RY14CHRNA7CHRNB2CHRNA4CHRNB4 | |
| SCHEMBL5938788 | 0.82 | CHRNA7 (0.52) | P2RY14CHRNA7CHRNB2CHRNA4CHRNB4 | |
| SCHEMBL5937537 | 0.82 | CHRNB2 (0.54) | P2RY14CHRNA7CHRNB2CHRNA4CHRNB4 | |
| SCHEMBL22805515 | 0.82 | P2RY14 (0.41) | P2RY14CHRNA7CHRNB2CHRNA4CHRNB4 | |
| SCHEMBL15596510 | 0.82 | CHRNB2 (0.54) | P2RY14CHRNA7CHRNB2CHRNA4CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2742045-B1 | ANTIBACTERIAL CYCLOPENTA[C]PYRROLE SUBSTITUTED 3,4-DIHYDRO-1H-[1,8]NAPHTHYRIDINONES | JANSSEN SCIENCES IRELAND UNLIMITED CO (IE) | 2019-01-23 | — | — | EP | disclosed |
| US-20180105525-A1 | ANTIBACTERIAL CYCLOPENTA[C]PYRROLE SUBSTITUTED 3,4-DIHYDRO-1H-[1,8]NAPHTHYRIDINONES | Janssen Sciences Ireland Unlimited Company (IE) | 2018-04-19 | — | — | US | disclosed |
| US-9884864-B2 | Antibacterial cyclopenta[C]pyrrole substituted 3,4-Dihydro-1H-[1,8]naphthyridinones | JANSSEN SCIENCES IRELAND UC (IE) | 2018-02-06 | — | — | US | disclosed |
| US-9884864-B2 | Antibacterial cyclopenta[C]pyrrole substituted 3,4-Dihydro-1H-[1,8]naphthyridinones | JANSSEN SCIENCES IRELAND UC (IE) | 2018-02-06 | — | — | US | disclosed |
| US-20170174683-A1 | ANTIBACTERIAL CYCLOPENTA[C]PYRROLE SUBSTITUTED 3,4-DIHYDRO-1H-[1,8]NAPHTHYRIDINONES | Janssen Sciences Ireland Unlimited Company (IE) | 2017-06-22 | — | — | US | disclosed |
| US-20170174683-A1 | ANTIBACTERIAL CYCLOPENTA[C]PYRROLE SUBSTITUTED 3,4-DIHYDRO-1H-[1,8]NAPHTHYRIDINONES | Janssen Sciences Ireland Unlimited Company (IE) | 2017-06-22 | — | — | US | disclosed |
| EP-2882738-B1 | NEW ANTIBACTERIAL COMPOUNDS | JANSSEN SCIENCES IRELAND UC (IE) | 2017-05-31 | — | — | EP | disclosed |
| US-9617262-B2 | Antibacterial cyclopental[C]pyrrole substituted 3,4-dihydro-1H-[1,8]naphthyridinones | JANSSEN SCIENCES IRELAND UC (IE) | 2017-04-11 | — | — | US | disclosed |
| US-9617262-B2 | Antibacterial cyclopental[C]pyrrole substituted 3,4-dihydro-1H-[1,8]naphthyridinones | JANSSEN SCIENCES IRELAND UC (IE) | 2017-04-11 | — | — | US | disclosed |
| US-20160194324-A1 | ANTIBACTERIAL CYCLOPENTAL[C]PYRROLE SUBSTITUTED 3,4 DIHYDRO-1H-[1,8]NAPHTHYRIDINONES | Janssen Sciences Ireland Unlimited Company (IE) | 2016-07-07 | — | — | US | disclosed |
| US-9290493-B2 | Antibacterial cyclopenta[c]pyrrole substituted 3,4-dihydro-1H-[1,8]naphthyridinones | JANSSEN SCIENCES IRELAND UC (IE) | 2016-03-22 | — | — | US | disclosed |
| US-20150210719-A1 | ANTIBACTERIAL COMPOUNDS | JANSSEN SCIENCES IRELAND US (IE) | 2015-07-30 | — | — | US | disclosed |
| US-20150210719-A1 | ANTIBACTERIAL COMPOUNDS | JANSSEN SCIENCES IRELAND US (IE) | 2015-07-30 | — | — | US | disclosed |
| US-20150080413-A1 | Antibacterial cyclopenta[c]pyrrole substituted 3,4-dihydro-1H-[1,8]naphthyridinones | Janssen Sciences Ireland Unlimited Company (IE) | 2015-03-19 | — | — | US | disclosed |
| US-20150080413-A1 | Antibacterial cyclopenta[c]pyrrole substituted 3,4-dihydro-1H-[1,8]naphthyridinones | Janssen Sciences Ireland Unlimited Company (IE) | 2015-03-19 | — | — | US | disclosed |
| US-8906923-B2 | Antibacterial cyclopenta[c]pyrrole substituted 3,4-dihydro-1H-[1,8]naphthyridinones | JANSSEN R&D IRELAND (IE) | 2014-12-09 | — | — | US | disclosed |
| US-8906923-B2 | Antibacterial cyclopenta[c]pyrrole substituted 3,4-dihydro-1H-[1,8]naphthyridinones | JANSSEN R&D IRELAND (IE) | 2014-12-09 | — | — | US | disclosed |
| US-20140171451-A1 | Antibacterial cyclopenta[c]pyrrole substituted 3,4-dihydro-1H-[1,8]naphthyridinones | JANSSEN R&D IRELAND (IE) | 2014-06-19 | — | — | US | disclosed |
| US-20140171451-A1 | Antibacterial cyclopenta[c]pyrrole substituted 3,4-dihydro-1H-[1,8]naphthyridinones | JANSSEN R&D IRELAND (IE) | 2014-06-19 | — | — | US | disclosed |
| WO-2014023814-A1 | NEW ANTIBACTERIAL COMPOUNDS | JANSSEN R&D IRELAND (IE) | 2014-02-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150080413-A1 | Antibacterial cyclopenta[c]pyrrole substituted 3,4-dihydro-1H-[1,8]naphthyridinones | ECI1, ALPI, PREP | P2RY14 4517/4885CHRNA7 4710/4885CHRNB2 4880/4885 |
| US-20140171451-A1 | Antibacterial cyclopenta[c]pyrrole substituted 3,4-dihydro-1H-[1,8]naphthyridinones | ECI1, ALPI, PREP | P2RY14 4517/4885CHRNA7 4710/4885CHRNB2 4880/4885 |
| US-20150210719-A1 | ANTIBACTERIAL COMPOUNDS | FAR1, GAA, ECI1 | P2RY14 4517/4885CHRNA7 4861/4885CHRNB2 4882/4885 |
| US-20160194324-A1 | ANTIBACTERIAL CYCLOPENTAL[C]PYRROLE SUBSTITUTED 3,4 DIHYDRO-1H-[1,8]NAPHTHYRIDINONES | ECI1, ALPI, CYP51A1 | P2RY14 4464/4885CHRNA7 4475/4885CHRNB2 4839/4885 |
| US-20170174683-A1 | ANTIBACTERIAL CYCLOPENTA[C]PYRROLE SUBSTITUTED 3,4-DIHYDRO-1H-[1,8]NAPHTHYRIDINONES | ECI1, ALPI, PREP | P2RY14 4517/4885CHRNA7 4710/4885CHRNB2 4880/4885 |
| US-20180105525-A1 | ANTIBACTERIAL CYCLOPENTA[C]PYRROLE SUBSTITUTED 3,4-DIHYDRO-1H-[1,8]NAPHTHYRIDINONES | ECI1, ALPI, PREP | P2RY14 4517/4885CHRNA7 4710/4885CHRNB2 4880/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.