Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.51 |
| ▸ | SSTR4 | P31391 | 6/20 | 0.50 |
| ▸ | KCNJ5 | P48544 | 2/20 | 0.45 |
| ▸ | KCNJ3 | P48549 | 2/20 | 0.45 |
| ▸ | AAK1 | Q2M2I8 | 5/20 | 0.39 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.37 |
| ▸ | SLC13A5 | Q86YT5 | 3/20 | 0.35 |
| ▸ | SLC13A2 | Q13183 | 1/20 | 0.35 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12145015 | 0.85 | KCNJ5 (0.42) | PTGS2SSTR4KCNJ5KCNJ3AAK1 | |
| SCHEMBL15599218 | 0.83 | SSTR4 (0.47) | PTGS2SSTR4AAK1NUDT1 | |
| SCHEMBL13313012 | 0.83 | PTGS2 (0.53) | PTGS2SSTR4KCNJ5KCNJ3AAK1 | |
| SCHEMBL17428846 | 0.81 | SSTR4 (0.45) | PTGS2SSTR4AAK1 | |
| SCHEMBL17244894 | 0.80 | PDE2A (0.43) | PTGS2SSTR4KCNJ5KCNJ3AAK1 | |
| SCHEMBL24599916 | 0.79 | SSTR4 (0.44) | PTGS2SSTR4AAK1 | |
| SCHEMBL12037978 | 0.77 | SLC13A5 (0.40) | SSTR4SLC13A5 | |
| SCHEMBL15599341 | 0.76 | SCN9A (0.44) | SSTR4AAK1 | |
| SCHEMBL15599223 | 0.75 | SCN9A (0.40) | PTGS2SSTR4AAK1NUDT1 | |
| SCHEMBL22746004 | 0.75 | SSTR4 (0.41) | PTGS2SSTR4AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014153037-A1 | SUBSTITUTED TRIAZOLOPYRIDINES AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2014-09-25 | — | — | WO | disclosed |
| WO-2014144545-A2 | SUBSTITUTED BENZOXAZOLES AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2014-09-18 | — | — | WO | disclosed |
| WO-2014008458-A2 | N-SUBSTITUTED BENZAMIDES AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2014-01-09 | — | — | WO | disclosed |